Experiment 569450
Worktypes
Compounds isolated
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | ORAL |
| Organism | Empty organism |
| Citation | KARBWANG,J: NA-BANGCHANG,K: THANAVIUL,A: LAOTHAVORN,P: DITTA-IN,M: HARINASUTA,T:. (1995). A COMPARATIVE CLINICAL TRIAL OF ARTEMETHER AND THE SEQUENTIAL REGIMEN OF ARTEMETHER-MEFLOQUINE IN MULTIDRUG RESISTANT FALCIPARUM MALARIA.. 36(6) |
| Amount utilized | |
| Compound isolated | |
| Disease | A RANDOMIZED COMPARATIVE CLINICAL TRIAL FOR ASSESSMENT OF THE EFFICACY OF TWO ANTIMALARIAL REGIMENS. ARTEMETHER ALONE AND THE SEQUENTIAL REGIMEN ARTEMETHER MEFLOQUINE WAS CARRIED OUT IN 109 THAI MALE PATIENTS WITH ACUTE UNCOMPLICATED MULTIDRUG RESISTANT FALCIPARUM MALARIA. FIFTY-THREE PANTENTS RECEIVED ORAL ARTEMETHER AT A TOTAL DOSE OF 700 MG(300 MG INITIALLY, FOLLOWED BY 100 MG DAILY FOR 4 DAYS). AND 56 PATIENTS RECEIVED THE SESQUENTIAL REGIMEN OF ARTEMETHER-MEFLOQUINE (300 MG ORAL ARTEMETHER INITALLY, FOLLOWED BY 750 MG ORAL MEFLOQUINE AFTER 24 H). PATIENTS IN BOTH GROUPS HAD A RAPID INITIAL RESPONSE TO TREATMENT, WITH A MEDIAN PARASITE CLEARANCE TIME OF 40 H COMPARED WITHG 43.5 H FOR THE SEQUENTIAL REGIMEN. MEDIAN FEVER CLEARANCE TIME WERE 42.5 H AND 32.5 H FOR ARTEMETHER AND THE SEQUENTIAL REGIMEN RESPECTIVELY. PARASITAEMIA REOCCURRED IN PATIENTS OF BOTH GROUPS DURING THE FOLLOW UP PEROID, 6 IN THE ARTEMETHER AND 3 IN THE SEQUENTIAL REIMEN(CURE RATES WERE 88 AND 94".) |
| Dose amount | 700.0 MG |
| Number | 1 |
| Qualitative result | ACTIVE |
| Animal | HUMAN ADULT |
| Per unit | DAY |
| Dose expression | DOSE |
| Gender | MALE |