Experiment 569529
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | ORAL |
| Organism | Teucrium chamaedrys (LAMIACEAE) |
| Citation | BEN YAHIA,M: MAVIER,P: METREAU,JM: ZAFRANI,ES: FABRE,M: GATINEAU-SALLANT,G: DHUMEAUX,D: MALLAT,A:. (1993). WILD GERMANDER-INDUCED CHRONIC ACTIVE HEPATITIS AND CIRRHOSIS: THREE CASES.. 17(12) |
| Amount utilized | |
| Compound isolated | |
| Disease | WE REPORT 3 CASES OF CHRONIC LIVER INJURY THAT WERE OBSERVED AFTER PROLONGED TREATMENT WITH WILD GERMANDER, A HERBAL MEDICINE RECENTLY PROHIBITED BY FRENCH MINISTRY OF HEALTH, FOLLOWING SEVERAL REPORTS SUGGESTING ITS HEPATOTOXICITY. CHRONIC ACTIVE HEPATITIS WAS FOUND IN 2 CASES, AND ACTIVE CIRRHOSIS IN CASE 1. THE ONSET OF HEPATITIS OCCURED AFTER 6 TO 7 MONATHS OF TREATMENT. SERUM ANTI-NUCLEAR AND ANTI-SMOOTH MUSCLE ANTIBODIES WERE PRESENT IN 2 PATIENTS. IN 2 CASES, WILD-GERMANDER INVOLVEMENT WAS RECOGNIZED SEVERAL MONTHS AFTER APPEARANCE OF LIVER INJURY. FOLLOWING TREATMENT DISCONTINUATION, OUTCOME WAS FAVORABLE IN THE 3 PATIENTS. THESE OBSERVATIONS SUGGEST THAT DIAGNOSIS OF ACUTE OF CHRONIC LIVER INJURY OF UNKNOWN ORIGIN SHOULD ALWAYS INCLUDE THE SEARCH FOR HERBAL MEDICINE TREATMENT. |
| Dose amount | 0.65 GM |
| Number | 1 |
| Qualitative result | ACTIVE |
| Animal | HUMAN ADULT |
| Per unit | PERSON |
| Dose expression | DOSE |
| Extract | PLANT |
| Gender | GIVEN TO BOTH SEXES |