Experiment 570057
Worktypes
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | IP |
| Organism | Panax ginseng (ARALIACEAE) |
| Citation | KIM,HS: ANN,SH: SEONG,YH: KIM,SH: OH,KW:. (1992). EFFECTS OF GINSENG TOTAL SAPONINS ON THE ANALGESIA AND TOLERANCE DEVELOPMENT OF PENTAZOCINE.. 16(2) |
| Amount utilized | |
| Compound isolated | |
| Disease | THIS STUDY EXAMINED THE INFLUENCE OF GINSENG TOTAL SAPONINS (GTS) ON THE ANALGESIC ACTION AND TOLERANCE DEVELOPMENT OF PENTAZOCINE IN MICE. PENTAZOCINE PROLONGED THE LATENCY TO RESPONSE IN ATHE TAIL FLICK RATHER THAN IN ATHE TAIL PINCH TEST. THE ANALGESIC EFFECT OF PENTAZOCINE WAS ANTAGONIZED BY NALOXONE AND COMPLETELY ELIMINATED BY PRETREATMENT WITH P-CHLOROPHENYLALANINE (PCPA). GTS PREVENTED THE PENTAZOCINE-INDUCED ANALGESIC AND INHIBITED THE DEVELOPMENT OF TOLERANCE TO PENTAZOCINE. THE ANTAGONISTIC EFFECT OF GTS ON THE PENTAZOCINE-INDUCED ANALGESIA WAS ABOLISHED BY 5-HTP, BUT NOT BY L-DOPA. THESE RESULTS SUGGEST THAT GTS INHIBITS HTE ANALGESIC ACTION OF PENTAZOCINE BY THE INTERACTION WITH SEROTONERGIC NEURON. |
| Dose amount | 100.0 MOL |
| Number | 1 |
| Qualitative result | ACTIVE |
| Animal | MOUSE |
| Per unit | KG |
| Dose expression | DOSE |
| Extract | SAPONIN FRACTION |