Experiment 570100
Worktypes
Compounds isolated
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | IV |
| Organism | Empty organism |
| Citation | RAADSTROEM,M: BENGTSSONK,J: EDERBERG,S: BENGTSSON,A: LOSWICK,AC: BENGTSON,JP:. (1995). EFFECTS OF EPHEDRINE ON OXYGEN CONSUMPTION AND CARDIAC OUTPUT.. 39(8) |
| Amount utilized | |
| Compound isolated | |
| Disease | THIS RANDOMIZED SINGLE-BLIND CROSS-OVER STUDY WAS DESIGNED TO SIMULTANEOUSLY EVALUATE CIRCULATORY, RESPIRATORY AND METABOLIC EFFECTS OF O.V.GIVEN EPHEDRINE IN 12 HEALTHY MALE VOLUNTEERS. OXYGEN UPTAKE AND CARBON DIOXIDE EXCRETION WERE MEASURED WITH INDRIECT CALORIMETRY AND NON-INVASIVE TRANSTHORACIC ELEC. BIOIMPEDANCE WAS USED FOR CARDIAC OUATPUT MEASUREMENTS. THE MAX. EFFECT ON MOST VARIABLES WAS REACHED AT 4-5 MIN. AT 5 MIN AFTER THE ADMINISTRATION OF EPHEDRINE 0.1 MG PER KG BODY WT THERE WERE SIGNIFICANT INCREASES IN CARDIAC INDEX, SYSTOLIC AND MEAN ARTERIAL BLOOD PRESSURE, EXPIRED MINUTE VOL., OXYGEN UPTAKE AND CORBON DIOXIDE EXCRETION RATES. THERE WERE NO SIGNIFICANT CHANGES IN THE QUOTIENT BETWEEN OXYGEN UPTAKE RATE AND CARDIAC INDEX (VO/CI) DURING THE 30 MIN STUDY PERIOD. THE O2 SATN. WAS NOT ALTERED. THE PRESENT STUDY INDICATES THAT EPHEDRINE INCREASES OXYGEN DEMAND AND SUPPLY IN A SIMILAR MAGNITUDE. |
| Dose amount | 0.1 MG |
| Number | 1 |
| Qualitative result | EQUIVOCAL |
| Animal | HUMAN ADULT |
| Per unit | KG |
| Dose expression | DOSE |
| Gender | MALE |