| Disease | THE EFFECT OF DIETARY SUPPLEMENTATION WITH DIFFERENT AMOUNTS OF FUNGAL OIL CONTAINING ARACHIDONIC ACID(AA, 20:4N-6) AND A MICROALGAL OIL CONTAINING DOCOSAHEXAENOIC ACID(DHA, 22:6N-3), BLENDED TO GIVE A RATIO OF AA TO DHA OF 1.25:1.00, ON PLASMA
LIPID AA, DHA, CHOLESTEROL, AND TRIACYLGLYCEROLS WAS EVALUATED IN HEALTHY MEN. SUBJECTS (N=8/GROUP) WERE GIVEN 28.8 G FAT/D CONTAINING 0% (O G AA,O G DHA), OR 1 X (0.8G AA, 0.6 G DHA), 3 X (2.2 G AA, 1.7 G DHA), OR 5 X (3.6 G AA, 2.9 G DHA) THE
ESTIMATED INTAKE OF INFANTS FED HUMAN MILK WITH 0.5% AA AND 0.4% DHA FOR 14 D. NO CLINICALLY SIGNIFICANT DOSE-RELATED EFFECTS WERE SEEN ON PHYSICAL EXAMINATION OR FROM ROUTINE LABORATORY TESTS. THE MICROALGAL-FUNGAL OIL BLEND RESULTED IN A
SIGNIFICANT, DOSE-DEPENDENT INCREASE IN PLASMA CHOLESTEROL AND PERCENTAGE PHOSPHOLIPID AA AND DHA, AND A DECREASE IN PERCENTATE TRIACYLGLYCEROLS AND PHOSPHOLIPID LINOLEIC ACID. PLASMA PHOSPHOLIPID AA AND DHA INCREASED 18% AND 50%, RESPECTIVELY,
WITH THE 1 X DOSE, SIMILAR TO THAT EXPECTED AT INTAKES PROVIDED BY HUMAN MILK. THESE OILS APPEAR TO BE SAFE DIETARY SOURCES OF AA AND DHA FOR HEALTHY ADULTS AT INTAKES EQUIVALENT TO 0.8 G AA. |