Experiment 576192
Worktypes
Compounds isolated
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Organism | Millettia thonningii (FABACEAE) |
| Citation | PERRETT,S: WHITFIELD,PJ:. (1995). AQUEOUS DEGRADATION OF ISOFLAVONOIDS IN AN EXTRACT OF MILLETTIA THONNINGII (LEGUMINOSAE) WHICH IS LARVICIDAL TOWARDS SHISTOSOMES.. 9(6) |
| Amount utilized | |
| Compound isolated | |
| Disease | A CHLOROFORM EXTRACT OF THE SEEDS OF THE WEST AFRICAN LEGUME MILLETTIA THONNINGII HAS BEEN SHOWN TO KILL THE SNAILS WHICH TRANSMIT THE SCHISTOSOMIASIS AND ALSO THE LARVAE OF THE PARASITE ITSELF. THIS STUDY EXAMINES THE BIOACTIVITY OF THE CHLOROFORM EXTRACT OF M.THONNINGII IN AQUEOUS NON-STERILE CONDITIONS. SUSPENSIONS OF THE EXTRACT IN WATER MAINTAINED LARVICIDAL ACTIVITY FOR LONG PEROIDS. HPLC ANALYSIS SHOWED THAT OVER A PERIOD OF 4 WEEKS IN AQUEOUS SUSPENSION, DEGRADATION OF TWO OF THE COMPOUNDS PRESENT, THE ISOFLAVONOIDS ALPINUMISOFLAVONE AND 4'-METHYLALPINUMISOFLAVONE, OCCURRED AND BIOACTIVITY WAS EVENTUALLY LOST, INDICATING THAT THESE COMPOUNDS ARE PROBABLY RESPONSIBLE FOR THE BIOACTIVITY. THESE ISOFLAVONOIDS ARE THOUGHT TO ACT VIA INHIBITION OF ELECTRON TRANSPORT. |
| Dose amount | 25.0 MCG |
| Number | 2 |
| Qualitative result | ACTIVE |
| Per unit | ML |
| Dose expression | CONC USED |
| Extract | CHCL3 EXT |