Experiment 596496
Worktypes
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | ORAL |
| Organism | Citrus paradisi (RUTACEAE) |
| Citation | BAILEY,DG: BEND,JR: ARNOLD,MO: TRAN,LT: SPENCE,JD:. (1996). ERYTHROMYCIN-FELODIPINE INTERACTION: MAGNITUDE, MECHANISM, AND COMPARISON WITH GRAPEFRUIT JUICE.. 60(1) |
| Amount utilized | |
| Compound isolated | |
| Disease | STUDY ON THE EFFECT OF ERYTHROMYCIN AND GRAPEFRUIT JUICE ON FELODIPINE PHARMACOKINETICS. CONCLUSIONS: ERYTHROMYCIN PRODUCED AN IMPORTANT PHARMACOKINETIC INTERACTION WITH FELOPDIPINE BY INHIBITION OF DRUG METABOLISM. ALTHOUGH ERYTHROMYCIN AND GRAPEFRUIT JUICE SHARED A COMMON MECHANISM, ERYTHROMYCIN LIKELY REDUCED FELODIPINE BIOTRANSFORMATION AT THE GUT WALL AND LIVER, WHEREAS SINGLE-DOSE GRAPEFRUIT JUICE HAD EFFECT MAINLY AT HTE GUT WALL. |
| Dose amount | 250.0 ML |
| Number | 1 |
| Qualitative result | ACTIVE |
| Animal | HUMAN ADULT |
| Dose expression | DOSE |
| Extract | JUICE |
| Gender | MALE |