| Disease | TOXICITY STUDIES WITH THE BUTANOL EXTRACT OF PUERARIA TUBEROSA DC. (LEGUMINOSAE), A PROSPECTIVE POSTCOITAL CONTRACEPTIVE AGENTS, WERE CARRIED OUT IN RATS. A DOSE OF 150 MG/KG WAS ADMINISTERED TO RATS FOR 6, 12, 18 AND 24 DAY6S. THE LEVEL OF
BLOOD SUGAR, SERUM PROTEINS, SERUM GPT AND GOT SHOWED VARIATIONS WITHIN THE NORMAL RANGE EXCEPT AT THE HIGHES DOSE REGIMEN. LEUCOCYTE COUNTS AND HAEMOGLOBIN VALUES WERE WITHIN NORMAL LIMITS. PROTEIN CONTENT, GLYCOGEN CONTENT, ACTIVITY OF ACID
AND ALKALINE PHOSPHATASE, LEVEL OF TOTAL AND ESTERIFIED CHOLESEROL, ADENOSINE TRIPHOSPHATASE, AND GLUCOSE 6-PHOSPHATASE ACTIVITY SHOWED NO SIGNIFICANT CHANGE AT INITIAL DURATIONS EXCEPT WITH THE 24 DAY REGIMEN. HOWEVER, THE ADRENAL GLANDS
SHOWED SIGNIFICANT CHANGE. IN ADDITION, NO SIGNIFICANT HISTOPATHOLIGICAL LESIONS WERE OBSERVED. IN CONCLUSION, THE BUTANOL EXTRACT APPEARS TO BE GENERALLY SAFE IN RATS AT THESE ACUTE AND SUBACUTE DOSAGE REGIMENS. |