Experiment 59868
Worktypes
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | INTRAGASTRIC |
| Organism | Brassica nigra (BRASSICACEAE) |
| Citation | SANCHEZ-PALOMERA,E:. (1951). CONCEPT OF THE MUCOUS BARRIER AND ITS SIGNIFICANCE.. 18() |
| Amount utilized | |
| Compound isolated | |
| Disease | GIVEN OIL AT CONC. OF 0.1-2.0% IN CORN OIL WAS PLACED IN STOMACH WITH PYLORIC AND ESOPHAGEAL ORIFICES LIGATED, FOR 3-10 HRS. 24-48 HRS LATER BIOPSY OF STOMACH WAS TAKEN. HYPEREMIA, LEUKOCYTIC INFILTRATION, EXTRAVASATION OF RBC'S AND EDEMA WERE NOTED. EPITHELIUM BECAME DETACHED FROM MUCOSA BUT WAS RESTORED 24-48 HRS LATER IF IRRITATION STOPPED. OTHERWISE, NECROSIS OF MUCOSA FOLLOWED. |
| Dose amount | VAR |
| Number | 1 |
| Qualitative result | ACTIVE |
| Animal | DOG |
| Dose expression | DOSE |
| Extract | ESSENTIAL OIL |