Experiment 59897
Compounds isolated
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | IN RATION |
| Organism | Empty organism |
| Citation | SCHOENTAL,R:. (1959). LIVER LESIONS IN YOUNG RATS SUCKLED BY MOTHERS TREATED WITH THE PYRROLIZIDINE (SENECIO) AKALOIDS, LASIOCARPINE AND RETRORSINE.. 77() |
| Amount utilized | |
| Compound isolated | |
| Disease | RETRORSINE WAS ADMINISTERED INTRAGASTRICALLY OR BY INTRAPERITONEAL INJECTION TO MOTHER RATS AT VARIOUS TIMES DURING PARTURITION. YOUNG RATS THEN SUCKLED THE MOTHERS AND THE EFFECT OF THE SUCKLING RATS WAS ASSAYED. THE DOSAGE RECEIVED VARIED FROM 25-40 MG IN 5-10 DOSES OF 5-10 MG TWICE WEEKLY OR MORE OFTEN. RATS EXHIBIT HEPATOTOXICITY AND DEATH. |
| Dose amount | VAR |
| Number | 2 |
| Qualitative result | ACTIVE |
| Animal | RAT |
| Dose expression | DOSE |