Experiment 602039

Worktypes

PHARMACOLOGY OF COMPOUND - IN HUMANSTOXICITY MARKER CODE

Compounds isolated

COUMARIN

Details

PropertyValue
Pharmacology
HEPATOTOXIC ACTIVITY
Administration routeORAL
OrganismEmpty organism
CitationGHOSH,P: MARKIN,RS: SORRELL,MF:. (1997). COUMARIN-INDUCED HEPATIC NECROSIS.. 92(2)
Amount utilized
Compound isolated
DiseaseCASE REPORT OF 66 YR OLD WITH PROSTATE CANCER WHO DEVELOPED HEPATITIS 15 WEEKS AFTER INITIATION OF THERAPY WITH GIVEN COMPOUND. REVIEW OF LITERATURE SUGGESTS NO RELATION TO DOSE DISCONTINUATION OF COMPOUND RESULTED IN RESOLUTION OF SYMPTOMS.
Number1
Qualitative resultACTIVE
AnimalHUMAN ADULT
Dose expressionDOSE
GenderMALE