Experiment 607123
Worktypes
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | ORAL |
| Organism | Serenoa repens (ARECACEAE) |
| Citation | CARRARO,JC: RAYNAUD,JP: KOCH,G: CHISHOLM,GD: DI SILVERIO,F: TEILLAC,P: DA SILVA,FC: CAUQUIL,J: CHOPIN,DK: HAMDY,FC: HANUS,M: HAURI,D: KALINTERIS,A: MARENCAK,J: PERIER,A: PERRIN,P:. (1996). COMPARISON OF PHYTOTHERAPY (PERMIXON) WITH FINASTERIDE IN THE TREATMENT OF BENIGN PROSTATE HYPERPLASIA: A RANDOMIZED INTERNATIONAL STUDY OF 1,098 PATIENTS.. 29(4) |
| Amount utilized | |
| Compound isolated | |
| Disease | A 6 MONTH, DOUBLE-BLIND RANDOMIZED EQUIALENCE STUDY COMPARED THE EFFECT OF SAW PALMETTO EXTRACT WITH FINASTERIDE (5 MG) IN MEN WITH MODERATE BPH USING THE INTERNATIONAL PROSTATE SYMPTOM SCORE AS THE PRIMARY AND POINT. BOTH PERMIXON AND FINASTERIDE DECREASED THE IPSS-(-37% AND 39%, RESPECTIVELY), IMPROVED QUALITY OF LIFE (BY 38 AND 41%), AND INCREASED PEAK URINARY FLOW RATE (+25% AMD +30%, P=0.035), WITH NOT STATISTICAL DIFFERENCE IN THE PERCENT OF RESPONDERS WITH A 3 ML/SEC IMPROVEMENT. FINASTERIDE MARKEDLY DECREASED PROSTATE VOLUME (-18%) AND SERUM PSA LEVELS (-41%); PERMIXON IMPROVED SYMPTOMS WITH LITTLE EFFECT ON VOLUME (-6%) AND NO CHANGE IN PSA LEVELS. PERMIXON FARED BETTER THAN FINASTERIDE IN A SEXULA FUNCTION QUESTIONNAIRE AND GAVE ROSE TO LESS COMPLAINTS OF DECREASED LIBIDO AND IMPOTENCE. BOTH TREATMENTS RELIEV THE SYMPTOMS OF BPH IN ABOUT TWO-THIRD OF PATIENTS BUT, UNLIKE FINASTERIDE, PERMIXON HAS LITTLE EFFECT ON SO-CALLED ANDROGEN- DEPENDENT PARAMETERS. THIS SUGGESTS THAT OTHER PATHWAYS MIGHT ALSO BE INVOLVED IN THE SYMPTOMATOLOGY OF BPH. |
| Dose amount | 320.0 MG |
| Number | 2 |
| Qualitative result | ACTIVE |
| Animal | HUMAN ADULT |
| Per unit | DAY |
| Dose expression | DOSE |
| Extract | HEXANE EXT |
| Gender | MALE |