Experiment 622386
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | ORAL |
| Organism | Serenoa repens (ARECACEAE) |
| Citation | TIMMERMANS,LMJ: TIMMERMANS JR,LGJ:. (1990). DETERMINATION OF THE ACTIVITY OF EXTRACTS OF ECHINACEAE.. 58(2) |
| Amount utilized | |
| Compound isolated | |
| Disease | A CLINICAL TRIAL ACTIVITY OF THE ECHINACEAE AND SABALAE EXTRACTS IN THE TREATMENT OF THE FEMALE IDIOPATHIC HYPOTONIC BLADDER. 30 PATIENTS (25 TO 76 YEARS OLD), SUFFERING FROM INCONTINENCE (18), POLLAKIURIA (6) AND DYSURIA (6) REVEAL AT THE URODYAMIC INVESTIGATION AN IDIOPATHIC LARGE HYPOTONIC BLADDER. 20 WERE TREATED BY ECHINACEAE (84 TO 112 MG/A DAY) A SABALAE (78 TO 104 MG/A DAY) EXTRACTS (URGENIN: 90 TO 120 DROPS/A DAY) DURING A MEAN TIME OF 77 DAYS. 10 HAVE RECEIVED 90 TO 120 DROPS/A DAY OF PLACEBO DURING A MEAN TIME OF 52 DAYS. AFTER PLACEBO NO MODIFICATION OF THE SYMPTOMATOLOGY AND NO SIGNIFICANT DIFFERENCE IN THE MEASURES WERE OBSERVED. AFTER URGENIN: THE BLADDER CAPACITY, THE RESIDUAL URINE AND THE COMPLIANCE ARE SIGNIFICANTLY DECREASED; THE DETRUSOR PRESSURE AND THE PEAK FLOW ARE SIGNIFICANTLY INCREASED. THE URETRAL PRESSURE, THE CLOSURE PRESSURE AND THE URETRAL INSTABILITY SHOW A NON-SIGNIFICANT DECREASE. THE MODIFICATIONS OF THE PROFILOMETERS AND SPHINCTER EMG ARE NOT SIGNIFICANT. |
| Dose amount | VAR |
| Number | 1 |
| Qualitative result | ACTIVE |
| Animal | HUMAN ADULT |
| Dose expression | DOSE |
| Extract | HYDRO-ALCOHOLIC EXT |
| Gender | FEMALE |