Experiment 623554
Worktypes
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | ORAL |
| Organism | Glycine max (FABACEAE) |
| Citation | POTTER,SM: BAUM,JA: TENG,HY: STILLMAN,RJ: SHAY,NF: ERDMAN JR,JW:. (1998). SOY PROTEIN AND ISOFLAVONES: THEIR EFFECTS OF BLOOD LIPIDS AND BONE DENSITY IN POSTMENOPAUSAL WOMEN.. 68(6S) |
| Amount utilized | |
| Compound isolated | |
| Disease | THE EFFECTS OF SOY PROTEIN (40 G/D) CONTAINING MODERATE AND HIGHER CONCENTRATIONS OF ISOFLAVONES ON BLOOD LIPID PROFILES. MONONUCLEAR CELL LDL RECEPTOR MESSENGER RNA, AND BONE MINERAL DENSITY AND CONTENT WERE INVESTIGATED IN 66 FREE-LIVING HYPERCHOLESTEROLEMIC, POSTMENOPAUSAL WOMEN DURING A 6-MO. PARALLEL-GROUP, DOUBLE-BLIND TRIAL WITH 3 INTERVENTIONS. AFTER A CONTROL PERIOD OF 14 D, DURING WHICH SUBJECTS FOLLOWED A NATIONAL CHOLESTEROL EDUCATION PROGRAM STEP I LOW-FAT, LOW- CHOLESTEROL DIET, ALL SUBJECTS WERE RANDOMLY ASSIGNED TO 1 OF 3 DIETARY GROUPS: STEP I DIET WITH 40 G PROTEN/D OBTAINED FROM CASEIN AND NONFAT DRY MILK (CNFDM), STEP I DIET WITH 40 G PROTEIN/D FROM ISOLATED SOY PROTEIN CONTAINING 1.39 MG ISO- FLAVONES/G PROTEIN (ISP56), OR STEP I DIET WITH 40 G PROTEIN/D FROM ISOLATED SOY PAROTEIN CONTAINING 2.25 MG ISOFLAVONE/G PROTEIN (ISP90). TOTAL AND REGIONAL BONE MINERAL CONTENT AND DENSITY WERE ASSESSED. NON-HDL CHOLESTEROL FOR BOTH ISP56 AND ISP90 GROUPS WAS REDUCED COMPARED WITH THE CNFDM GROUP (P< 0.05). HDL CHOLESTEROL INCREASED IN BOTH ISP56 AND ISP90 GROUPS (P< 0.05). MONONUCLEAR CELL LDL RECEPTOR MRNA WAS INCREASED IN SUBJECTS CONSUMING ISP56 OR ISP90 COMPARED WITH THOSE CONSUMING CNFDM (P< 0.05). SIGNIFICANT INCREASES OCCURRED IN BOTH BONE MINERAL CONTENT AND DENSITY IN THE LUMBAR SPINE BUT NOT ELSEWHERE FOR THE ISP90 GROUP COMPARED WITH THE CONTROL GROUP (P< 0.05). INTAKE OF SOY PROTEIN AT BOTH ISOFLAVONE CONCENTRATIONS FOR 6 MO MAY DECREASE THE RISK FACTORS ASSOCIATED WITH CARDIOVASCULAR DISEASE IN POSTMENOPAUSAL WOMEN. HOWEVER, ONLY THE HIGHER ISOFLAVONE-CONTAINING PRODUCT PROTECTED AGAINST SPINAL BONE LOSS. |
| Dose amount | VAR |
| Number | 1 |
| Qualitative result | ACTIVE |
| Animal | HUMAN ADULT |
| Dose expression | DOSE |
| Extract | SEEDS |
| Gender | FEMALE |