Experiment 623573

Details

PropertyValue
Pharmacology
Administration routeORAL
OrganismEchinacea angustifolia (ASTERACEAE)
CitationBENDEL,R: BENDEL,V: RENNER,KH: STOLZE,K:. (1988). ADDITIONAL TREATMENT WITH ESBERITOX IN PATIENTS SUBMITTED TO CURATIVE ADJUVANT IRRADIATION AFTER MAMMARY CARCINOMA.. 164(5)
Amount utilized
Compound isolated
DiseaseTHE STUDY WAS SUPPOSED TO INVESTIGATE A POSSIBLE PREVENTION OR REDUCTION OF THE TOXICITY OF RADIOTHERAPY BY AN ADDITIONAL TREATMENT WITH ESBERITOX. THIS QUESTION ARISES WHEN PERFORMING AN INVESTIGATION ABOUT THE EFFECT OF ESBERITOX IN A COMBINED CHEMO-RADIOTHERAPY. WHEREAS THE LATTER INDUCED ABOVE ALL A SYSTEMIC DAMAGE TO THE HEMOPOIETIC SYSTEM, RADIOTHERAPY IS A REGIONAL NOXA. 2. THE PRESENT PROSPECTIVE, RANDOMIZED STUDY WAS CONDUCTED WITH 50 PATIENTS SUBMITTED TO CURATIVE ADJUVANT IRRADIATION FOLLOWING TO SURGERY FOR MAMMARY CARCINOMA. THE RADIOTHERAPY WAS PERFORMED IN THE SAME WAY IN ALL PATIENTS WITH IRRADIATIONS OF THE THORACIC WALL AND THE REGIONAL LYMPH NODES. TWO GROUPS WERE BUILT BY RANDOMIZATION. THE STUDY GROUP RECEIVED AN ADDITIONAL TREATMENT WITH ESBERITOX, THE CONTROL GROUP DID NOT RECEIVE AN ADDITIONAL TREATMENT. 3. AS A RESULT, NO PROTECTIVE INFLUENCE OF ESBERITOX COULD BE DEMONSTRATED. THE PARAMETERS INVESTIGATED WERE THE PERIPHERAL BLOOD COUNT (LEUCOCYTES, GRANULOCYTES, LYMPHOCYTES, MONOCYTES, THROMBOCYTES, HEMOGLOBIN, HEMATOCRIT) AND THE INCIDENCE OF INFECTIONS.
Dose amountVAR
Number1
Qualitative resultINACTIVE
AnimalHUMAN ADULT
Dose expressionDOSE
ExtractHYDRO-ALCOHOLIC EXT
GenderFEMALE