Experiment 624562
Worktypes
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | ORAL |
| Organism | Echinacea purpurea (ASTERACEAE) |
| Citation | GRIMM,W: MULLER,HH:. (1999). A RANDOMIZED CONTROLLED TRIAL OF THE EFFECT OF FLUID EXTRACT OF ECHINACEA PURPUREA ON THE INCIDENCE AND SEVERITY OF COLDS AND RESPIRATORY INFECTIONS.. 106(2) |
| Amount utilized | |
| Compound isolated | |
| Disease | A TOTAL OF 109 PATIENTS WITH A HISTORY OF MORE THAN 3 COLDS OR RESPIRATORY INFECTIONS IN THE PRECEDING YEAR WERE RANDOMLY ASSINGED TO RECEIVE 4 ML FLUID EXTACT OF ECHINACEA PURPUREA OR 4 ML PLACEBO-JUICE TWICE A DAY IN A DOUBLE-BLIND MANNER. THE INCIDENCE AND SEVERITY OF COLDS AND RESPIRATORY INFECTIONS WERE DETERMINED DURING 8 WEEKS OF FOLLOW-UP, BASED ON PATIENT REPORTED SYMPTOMS TOGETHER WITH FINDINGS ON PHYSICAL EXAM. THE SEVERITY OF EACH INFECTION WAS GRADED BY THE INVESTIGATORS. RELATIVE RISKS (RR) AND 95% CONFIDENCE INTERVALS (CI) WERE ESTIMATED. DURING THE 8 WEEKS TREATMENT PERIOD, 35 (65%) OF 54 PATIENTS IN THE ECHINACEA GROUP AND 40 (74%) OF 54 PATIENTS IN THE PLACEBO GROUP HAD AT LEAST ON COLD OR RESPIRATORY INFECTION [RR=0.88; 95% CI (0.60, 1.22)]. THE AVERAGE NUMBER OF COLDS AND RESPIRATORY INFECTIONS PER PATIENT WAS 0.78 IN THE ECHANACEA GROUP, AND 0.93 IN THE PLACEBO GROUP [DIFFERENCE=0.15; 95% CI (-0.12, 0.41), P=0.33]. MEDIAN DURATION OF COLD AND RESPIRATORY INFECTIONS WAS 4.5 DAYS IN THE ECHINACEA GROUP AND 6.5 DAYS IN THE PLACEBO GROUP (95% CI: -1, +3 DAYS; P=0.45). THERE WERE NO SIGNIFICANT DIFFERENCE BETWEEN TREATMENT GROUPS IN THE NUMBER OF INFECTIONS IN EACH CATEGORY OF SEVERITY. SIDE EFFECTS WERE OBSERVED IN 11 PATIENTS (20%) OF THE ECHINACEA GROUP AND IN SEVEN PATIENTS (13%) OF THE PLACEBO GROUP (P=0.44). TREATMENT WITH FLUID EXTRACT OF ECHINACEA PURPUREA DID NOT SIGNIFICANTLY DECREASE THE INCIDENCE, DURATION OF COLDS AND RESPIRATORY INFECTIONS AS COMPARED WITH PLACEBO. |
| Dose amount | 4.0 ML |
| Number | 1 |
| Qualitative result | INACTIVE |
| Animal | HUMAN ADULT |
| Per unit | DAY |
| Dose expression | DOSE |
| Extract | FLUIDEXTRACT |
| Gender | GIVEN TO BOTH SEXES |