Experiment 624565

Worktypes

CLINICAL STUDIES

Details

PropertyValue
Pharmacology
COMMON COLD RELIEF
Administration routeORAL
OrganismEchinacea purpurea (ASTERACEAE)
CitationBRAUNIG,B: DORN,M: KNICK,E:. (1992). ENHANCEMENT OF RESISTANCE IN COMMON COLD BY ECHINACEA PURPUREA RADIX.. 13()
Amount utilized
Compound isolated
DiseaseIN A MONOCENTER PLACEBO-CONTROLLED DOUBLE-BLIND STUDY, AN EXTRACT FROM ECHINACEA ROOT WAS INVESTIGATED FOR ITS THERAPEUTIC EFFICACY IN PATIENTS SUFFERING FROM COMMON COLD. THIS INVOLVED A THREE-ARMED STUDY IN WHICH 60 PATIENTS RECEIVED A PLACEBO PREPARATION (GROUP1), 60 PATIENTS DOSE 1 (GROUPII) AND A FURTHER 60 PATIENTS DOSE 2 (GROUPIII). THE EFFECT OF SELECTED SYMPTOMS AND CLINICAL FINDINGS INCLUDING LABORATORY PARAMETERS WAS TESTED AFTER 3-4 DAYS AND 8-10 DAYS. DOSE 1 WAS NOT FOUND TO HAVE ANY MARKED EFFICACY COMPARED WITH PLACEBO AFTER 3-4 DAYS OR AFTER 8-10 DAYS. THIS CONTRACTS WITH THE EFFICACY IN DOSE GROUP 2 (DOUBLE DOSED IN WHICH SIGNIFICANT DIFFERENCES WERE MEASURED IN A RANGE OF PARAMETERS AND THUS BETTER EFFICACY COMPARED WITH PLACEBO. A SEPARATE EVALUATION OF PATIENTS WITH PURELY VIRAL INFECTIONS COMPARED WITH MAINLY BACTERIAL INFECTIONS MADE A DIFFERENTIATED ASSESSMENT POSSIBLE. HOWEVER, THESE INDIVIDUAL FINDINGS DO NOT PERMIT A DIFFERENTIATION OF CLINICAL PARAMETERS. ON THE BASIS OF SELECTED PARAMETER "SUM OF SCORES OF THE CLINICAL FINDINGS" A STATISTICALLY SIGNIFICANT DOSE DEPENDENCY OF THE ACTION OF THE ECHINACEA EXTRACT COULD BE DETERMINED IN COMPARISON WITH PLACEBO. IT COULD BE SHOWED THAT A 55% ETHANOLIC EXTRACT (5:1) OF ECHINACEA PURPUREA RADIX AT A DAILY DOSE OF 180 DROPS (900 MG DRUG/DAY) OF EXTRACT IS ABLE TO CLEARLY IMPROVE THE SYMPTOMS IN THE INDICATION "ENHANCEMENT OF RESISTANCE IN COMMON COLD AND FEBRILE INFECTIONS OF THE UPPER RESPIRATORY TRACT".
Dose amount450.0 MG
Number2
Qualitative resultINACTIVE
AnimalHUMAN ADULT
Per unitDAY
Dose expressionDOSE
ExtractETOH(95%)EXT
GenderGIVEN TO BOTH SEXES