Experiment 625145

Details

PropertyValue
Pharmacology
Administration routeORAL
OrganismAllium sativum (LILIACEAE)
CitationGRAHAM,DY: ANDERSON,SY: LANG,T:. (1999). GARLIC OR JALAPENO PEPPERS FOR TREATMENT OF HELICOBACTER PYLORI INFECTION.. 94(5)
Amount utilized
Compound isolated
DiseaseA PROPECTIVE CROSSOVER STUDY IN HEALTHY H.PYLORI-INFECTED ADULTS WAS PERFORMED VIA UREA BREATH TEST TO ASSESS THE STATUS OF THE H. PYLORI INFECTION. ON SEPARATION DAYS SUBJECTS RECEIVED THREE TEST MEALS CONSISTING OF BEEF, TORTILLAS, AND SALAD WITH ONE OF THE FOLLOWING: FRESH GARLIC (10 SLICED CLOVES), CAPSAICIN (SIX SLICED FRESH JALAPENOS), TWO TABLETS OF BISMUTH SUBSALICYLATE (PEPTO-BISMOL, POSITIVE CONTROL), OR NOTHING ADDED (NEGATIVE CONTROL). BREATH TESTING WAS DONE BEFORE THE FIRST MEAL, THE EVENING MEAL, AND THE FOLLOWING MORNING. AT LEAST 2 DAYS ELAPSED BETWEEN THE TEST SUBSTANCES. TWELVE SUBJECTS PARTICIPATED (SEVEN MEN, FIVE WOMEN), WITH AN AVERAGE AGE OF 41.4 YR, RANGE 27-51 YRS. TEN SUBJECTS RECEIVED GARLIC, SIX RECEIVED JALAPENOS, AND 11 RECEIVED BISMUTH, NEITHER GARLIC NOR CAPSAICIN HAD ANY IN VIVO EFFECT ON H. PYLORI (MEDIAN UREASE ACTIVITY 28.5 VS 39.8 AND 43.7 VS 46.6 BEFORE AND AFTER GARLIC AND JALAPENOS, RESPECTIVELY) (P<0.8). BISMUTH HAD A MARKED INHIBITORY EFFECT (MEDIAN 55.8 VS. 14.3 BEFORE AND AFTER BISMUTH) (P<0.001), RESPECTIVELY.
Number1
Qualitative resultINACTIVE
AnimalHUMAN ADULT
Dose expressionDOSE
ExtractROOT
GenderGIVEN TO BOTH SEXES