Experiment 626229
Worktypes
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | ORAL |
| Organism | Aesculus hippocastanum (HIPPOCASTANACEAE) |
| Citation | SCHRODTER,A: LOEW,D: SCHWANKL,W: RIETBROCK,N:. (1998). VALIDITY OF PHARMACOKINETIC DATA OF BETA-ESCIN FROM HORSE CHESTNUT SEED EXTRACTS DETERMINED BY RADIOIMMUNOLOGICAL METHODS.. 48(9) |
| Amount utilized | |
| Compound isolated | |
| Disease | THE BIOAVAILABILITY UNDER STEADY STATE CONDITIONS OF A STANDARD, SLOW-RELEASE HORSE CHESTNUT SEED EXTRACT (HCSE)-CONTAINING PRODUCT WAS COMPARED WITH THAT OF AN ANALOGOUS, FAST-RELEASE TEST PREPARATION (NORICAVEN NOVO) IN A PROSPECTIVE, RANDOMISED, DOUBLE-BLIND STUDY IN A DOUBLE CROSS-OVER DESIGN. THE SERUM CONCENTRATION OF BETA-ESCIN (CAS 6805-41-0) WAS MEASURED BY RADIOIMMUNOASSAY. THE PHARMACOKINETICS OF THIS STUDY WERE COMPARED WITH THE CORRESPONDING DATA OF A SIMILAR INVESTIGATION CARRIED OUT UNDER ANALOGOUS CONDITIONS CONCERNING STUDY DESIGN, ANALYTICAL METHODS AND REFERENCE PREPARATION. COMPARISON OF THE SIMILAR STUDIES REVEALED DIFFERENCES IN CHARACTERISTIC PHARMAKOKINETIC VALUES OF BETA-ESCIN IN TERMS OF A SHIFT OF THE CONCENTRATION CURVES AS COULD BE DEMONSTRATED FOR THE REFERENCE PRODUCT. THE TOTAL AMOUNTS OF ESCIN IN THE TWO PRODUCTS INVESTIGATED DID NOT DIFFER SIGNIFICANTLY, HOWEVER, QUANTITATIVE AND QUALITATIVE DIFFERENCES WERE DETECTED IN THE CONSTITUENTS OF THE TWO DIFFERENT EXTRACT PREPARATIONS. |
| Dose amount | 50.0 MG |
| Number | 1 |
| Qualitative result | ACTIVE |
| Animal | HUMAN ADULT |
| Dose expression | DOSE |
| Extract | HYDRO-ALCOHOLIC EXT |
| Gender | GIVEN TO BOTH SEXES |