Experiment 626230
Worktypes
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | ORAL |
| Organism | Citrus paradisi (RUTACEAE) |
| Citation | GARG,SK: KUMAR,N: BHARGAVA,VK: PRABHAKAR,SK:. (1998). EFFECT OF GRAPEFRUIT JUICE ON CARBAMAZEPINE BIOAVAILABILITY IN PATIENTS WITH EPILEPSY.. 64(3) |
| Amount utilized | |
| Compound isolated | |
| Disease | A RANDOMIZED CROSSOVER STUDY CONSISTING OF 2 PHASES. TEN PATIENTS WITH EPILEPSY WHO HAD RECEIVED THERAPY WITH 200 MG CARBAMAZEPINE 3 TIMES A DAY FOR THE PREVIOUS 3 TO 4 WEEKS PARTICIPATED. THEY WERE GIVEN EITHER GRAPEFRUIT JUICE OF 300 ML WATER AT 8 AM ALONG WITH 200 MG CARBAMAZEPINE. EACH TREATMENT WAS SEPARATED BY 2 DAYS; SUBJECTS CONTINUED TO RECEIVE CARBAMAZEPINE THERAPY DURING THE 2-DAY PEROID. ON BOTH OCCASIONS, BLOOD SAMPLES WERE COLLECTED AT DIFFERENT TIME INTERVALS BETWEEN 0 TO 8 HOURS. CARBAMAZEPINE LEVELS WERE ESTIMATED BY REVERSED-PHASE HPLC TECHNIQUE. COMPARED WITH WATER, GRAPEFRUIT JUICE SIGNIFICANTLY INCREASED THE STEADT-STATE OEAJ CIBCEBTRATUIB (6.55 VERSUS 9.20 MLG/ML), TROUGH CONCENTRATION (4.51 VERSUS 6.28 MLG/ML), AND AREA UNDER THE PLASMA CONCENTRATION-TIME CURVE (43.99 VERSUS 61.95 ULG.H/ML) OF CARBAMAZEPINE. NO SIGNIFICANT EFFECT WAS FOUND IN THE TIME TO REACH PEAK PLASMA CONCENTRATION. GRAPEFRUIT JUICE INCREASES THE BIOAVALABILITY OF CARBAMAZEPINE BY INHIBITING CYP3A4 ENZYMES IN GUT WALL AND IN THE LIVER. |
| Dose amount | 300.0 MG |
| Number | 1 |
| Qualitative result | . |
| Animal | HUMAN ADULT |
| Per unit | PERSON |
| Dose expression | DOSE |
| Extract | JUICE |
| Gender | GIVEN TO BOTH SEXES |