Experiment 626292
Worktypes
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | ORAL |
| Organism | Vitis vinifera (VITACEAE) |
| Citation | FOLTS,JD:. (1998). ANTITHROMBOTIC POTENTIAL OF GRAPE JUICE AND RED WINE FOR PREVENTING HEART ATTACTS.. 36() |
| Amount utilized | |
| Compound isolated | |
| Disease | THE PLATELET INHIBITORY EFFECTS OF RED AND WHITE WINE AND PURPLE GRAPE JUICE IN 10 HEALTHY HUMAN SUBJECTS WERE TESTED. BLOOD SAMPLES WERE OBTAINED FOR WHOLE BLOOD AGGREGOMETRY BEFORE AND AFTER EACH FASTING SUBJECT CONSUMED 5 ML/KG OF EITHER A FRENCH RED WINE, FRENCH WHITE WINE, OR 12 MG/KG OF PURPLE GRAPE JUICE. THERE WAS A 7-DAY WASHOUT PEROID BETWEEN CONSUMPTION OF EACH BEVERAGE. IN THE 10 SUBJECTS, WHOLE BLOOD PLATELET AGGREGATION IN RESPONSE TO COLLAGEN DECREASED BY 39 DL 11% (P <0.01) AND BY 28 DL 106% (P <0.05) IN RESPONSE TO ADP AFTER THE RED WINE BUT THERE WERE NO SIGNIFICANT CHANGES AFTER THE WHITE WINE. BLOOD ALCOHOL CONTENT AVERAGED 0.06 G/DL AFTER BOTH WINES. THE PURPLE GRAPE JUICE DECREASED COLLAGEN-INDUCED PLATELET AGGREGATION BY 34 DL 11% (P <0.03) AND ADP-INDUCED AGGREGATION BY 24 DL 12% (P <0.05). |
| Dose amount | 5.0 ML |
| Number | 1 |
| Qualitative result | ACTIVE |
| Animal | HUMAN ADULT |
| Per unit | KG |
| Dose expression | DOSE |
| Extract | JUICE |
| Gender | GIVEN TO BOTH SEXES |