Experiment 626306
Worktypes
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | ORAL |
| Organism | Linum usitatissimum (LINACEAE) |
| Citation | NESBITT,PD: LAM,Y: THOMPSON,LU:. (1999). HUMAN METABOLISM OF MAMMALIAN LIGNAN PRECURSORS IN RAW AND PROCESSED FLAXSEED.. 69(3) |
| Amount utilized | |
| Compound isolated | |
| Disease | NINE HEALTHY YOUNG WOMEN SUPPLEMENTED THEIR DIETS WITH 5,15 OR 25 G RAW OR 25 G PROCESSED (MUFFIN OR BREAD) FLAXSEED FOR 7 D DURING THE FOLLICULAR PHASE OF THEIR MENSTRUAL CYCLES. TWENTY-FOUR-HOUR URINE SAMPLES WERE COLLECTED AT BASELINE AND ON THE FINAL DAY OF SUPPLEMENTATION. AS AN ADJUNCT TO THE 25-G-FLAXSEED ARM, SUBJECTS CONSUMED THE SUPPLEMENT FOR AN ADDITIONAL DAY AND BLOOD AND URINE SAMPLES WERE COLLECTED AT SPECIFIC INTERVALS. ALL BLOOD AND URINE SAMPLES WERE ANALYZED FOR ENTEROLACTONE AND ENTERODIOL BY GAS CHROMATOGRAPHY-MASS SPECTROSCOPY. RESULTS: A DOSE-DEPENDENT URINARY LIGNAN RESPONSE TO RAW FLAXSEED WAS OBSERVED (R=0.72, P< 0.001). THE PROCESSING OF FLAXSEED AS A MUFFIN OR BREAD DID NOT EFFECT THE QUANTITY OF LIGNAN EXCRETION. PLASMA LIGNAN CONCENTRATIONS WERE GREATER (P < 0.05) THAN BASELINE BY 9 H AFTER FLAXSEED INGESTION (29.35 DL 3.69 AND 51.75 DL 7.49 NMOL/L, RESPECTIVELY). THE TOTAL PLASMA AREA UNDER THE CURVE WAS HIGHER ON THE EIGHT THAN ON THE FIRST DAY (1840.15 DL 343.02 AND 1027.15 DL 95.71 NMOL-H/L, RESPECTIVELY. |
| Dose amount | VAR |
| Number | 1 |
| Qualitative result | . |
| Animal | HUMAN ADULT |
| Dose expression | DOSE |
| Extract | SEEDS |
| Gender | FEMALE |