Experiment 626639
Worktypes
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | ORAL |
| Organism | Ginkgo biloba (GINKGOACEAE) |
| Citation | RONCIN,JP: SCHWARTZ,F: D'ARBIGNY,P:. (1996). EGB 761 IN CONTROL OF ACUTE MOUNTAIN SICKNESS AND VASCULAR REACTIVITY TO COLD EXPOSURE.. 67(5) |
| Amount utilized | |
| Compound isolated | |
| Disease | 44 SUBJECTS PARTICIPATED IN A STUDY OF THE PREVENTIVE EFFECT OF GINKGO BILOBA EXTRACT (EGB 761) ON ACUTE MOUNTAIN SICKNESS (AMS) AND VASOMOTOR CHANGES OF THE EXTREMITIES DURING A HIMALAYAN EXPEDITION. THE SUBJECTS WERE RANDOMIZED TO TWO GROUPS. ONE GROUP RECEIVED 160 MG OF EGB 761 PER DAY IN TWO DIVIDED DOSES AND THE OTHER GROUP RECEIVED PLACEBO. ASSESSMENT WAS BASED ON THE COURSE OF THE ENVIROMENTAL SYMPTOM QUESTIONNAIRE (ESQ) SCORE AND THE COLD GRADIENT MEASURED BY PHOTOPLETHYSMOGRAPHY. THE PROPHYLACTIC EFFICACY OF TREATMENT WITH EGB 761 WAS CLEARLY DEMOONSTRATED IN THIS STUDY. IN TERMS OF FACTOR MOUTAIN SICKNESS VERSUS 40.9% OF SUBJECTS IN THE PLACEBO GROUP; THIS DIFFERENCE WAS VERY SIGNIFCANT (P<1.4 X 10-3). IN TERMS OF FACTOR 2 (AMS-RESPIRATORY), 3 SUBJECTS (13.6%) IN THE EGB 761 GROUP DEVELOPED ACUTE MOUNTAIN SICKNESS VERSUS 18 (81.8%) IN THE PALCEBO GROUP; THIS DIFFERENCE WAS VERY SIGNIFICANT (P =1.2 X 10-5). EGB 761 PROVIDES AN INTERESTING RESPONSE TO THE PREVENTION OF MOUNTAIN SICKNESS FOR MODERATE ALTITUDE (5400 M) WITH GRADUAL EXPOSURE. IT ALSO DECREASED VASOMOTOR DISORDERS OF THE EXTREMITIES, AS DEMONSTRATED BY PLETHYSMOGRAPHY (P< 10-8) AND A SPECIFIC QUESTIONNAIRE (P<10-9). A COMMERCIAL PRODUCT, EGB-761, WAS USED. |
| Dose amount | 160.0 MG |
| Number | 1 |
| Qualitative result | ACTIVE |
| Animal | HUMAN ADULT |
| Per unit | DAY |
| Dose expression | DOSE |
| Extract | ETOH(100%)EXT |
| Gender | GIVEN TO BOTH SEXES |