Experiment 626643

Details

PropertyValue
Pharmacology
Administration routeORAL
OrganismSauropus androgynus (EUPHORBIACEAE)
CitationKAO,CH: HO,YJ: WU,CL: CHANGLAI,SP:. (1999). USING 99M TC-DTPA RADIOAEROSOL INHALATION LUNG SCINTIGRAPHIES TO DETECT THE LUNG INJURY INDUCED BY CONSUMING SAUROPUS ANDROGYNUS VEGETABLE AND COMPARISON WITH CONVENTIONAL PULMONARY FUNCTION TESTS.. 66(1)
Amount utilized
Compound isolated
DiseaseCASE REPORTS OF LUNG INJURY DUE TO THE INGESTION OF SAUROPUS ANDROGYNUS. THIRTY-SIX CASES HAD RESPIRATORY SYMPTOMS/SIGNS AND THE REMAINING 45 HAD NO SYMPTOMS/SIGNS. THE PATIENTS WERE ASSESSED WITH PULMONARY FUNCTION TESTS (PFT) AND TECHNETIUM- 99M DPTA RADIOEROSOL INHALATION LUNG SCINTIGRAPHIES (DPTA LUND SCAN), A TEST TO EVALUATE THE LUNG VENTIALTION AND ALVEOLAR EPITHELIAL PERMEABILITY. EIGHTEEN PATIENTS HAD ABNORMAL RESULTS IN PFT, INCLUDING OBSTRUCTION TYPE (N=17), RESTRICTIVE TYPE (N=5), AND BOTH (N=4). THERE WERE 33 PATIENTS WITH ABNORMALITIES IN DTPA LUNG SCANS, INCLUDING UNHOMOGENEOUS DEPOSITION OF DTPA RADIOAEROSOLS (N=19), FASTER CLEARANCE OF RADIOASEROSOLS FROM LUNG (N=26), AND BOTH (N=12). ANALYZING THE RESULT , THE PATIENTS WITH RESPIRATORY SYMPTOMS HAD A HIGHER INCIDENCE OF ABNORMAL RESULTS OF PFT AND DTPA LUNG SCANS THAN THE PATIENTS WITHOUT RESPIRATORY SYMTPOMS (P<0.05). THE DTPA LUNG SCAN WAS MORE SENSITIVE THAN CHEST X-RAY AND PFT IN DETECTING THE LUNG INJURIES RELATED TO THE CONCUMPTION OF S. ANDROGYNUS (P<0.05). CONSUMING S. SNDROGYNUS CAN RESULT IN SYMPTOMATIC OR ASYMPTOMATIC LUNG INJURIES, MANIFESTED AS OBSTRUCTIVE OR RESTRICTIVE VENTILATORY IMPARIMENT, UNHOMOGENOUS RADIOAEROSOL DISTRIBUTION, AND INCREASED ALVEOLAR EPITHELIAL PERMEABILITY. IN ADDITION, MEASUREMENT OF THE 99M TC-DTPA CLEARANCE IS THE MOST SENSITIVE TEST TO DETECT THE LUNG INJURIES CAUSED BY CONSUMING S.ANDROGYNUS.
Dose amountVAR
Number1
Qualitative resultACTIVE
AnimalHUMAN ADULT
Dose expressionDOSE
ExtractLEAVES
GenderFEMALE