Experiment 626748
Worktypes
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | ORAL |
| Organism | Sanguinaria canadensis (PAPAVERACEAE) |
| Citation | TENEBRUM,H: DAHAN,M: SOELL,M:. (1999). EFFECTIVENESS OF A SANGUINARINE REGIMEN AFTER SCALING AND ROOT PLANING.. 70(3) |
| Amount utilized | |
| Compound isolated | |
| Disease | SIXTY PATIENTS DIAGNOSED AS HAVING ADULT PERIDODONTITIS RECEIVED INITIAL PERIODOTAL THERAPY INCLUDING SCALING AND ROOT PLANING, FOLLOWED BY A 2-WEEK ORAL CARE REGIMEN WHICH INCLUDED RINSING WITH 0.2% CHLORHEXIDINE GLUCONATE ORAL RINSE. UPON COMPLETION OF THIS 2-WEEK INITIAL THERAPY PHASE, PATIENTS WER RANDOMLY ASSIGNED TO EITHER SANGUINARINE TOOTH-PASTE AND ORAL RINSE OR TO CONTROL TOOTHPASTE AND ORAL RINSE WITHOUT SANGUINARINE. PLAQUE (MODIFIED QUIGLEY-HEIN INDEX) AND GINVIVITIES (GINGIVAL INDEX) WERE MEASURED PRIOR TO PERIODONTAL THERAPY, AT THE END OF THE CHLORHEXIDINE PHASE (2 WEEKS), AND AFTER 8 OR 14 WEEKS. SANGUINARINE-CONTAINING TOOTHPASE AND ORAL RINSE SIGNIFICANTLY INHIBITED THE REDEVELOPMENT OF GINGIVITIS THROUGH THE 12 WEEKS FOLLOWING THE CHLORHEXIDINE PHASE COMPARED TO THE CONTROL TOOTHPASE AND RINSE. PATIENTS IN THE TEST GROUP HAD 26% FEWER BLEEDING SITES AT 8 WEEKS, AND 32% FEWER AT 14 WEEKS, THAN THE CONTROL GROUP. THE RESULTS SUPPORT THE COMBINED US OF CHLORHEXIDINE MOUTHRINSE FOR A SHORT TERM (2 WEEKS) FOLLOWED BY SANGUINARIA MOUTHRINSE AND TOOTHPASE UP TO 3 MONTHS IN ORDER TO OPTIMIZE THE EFFECTIVESESS OF CHLORHEXIDINE WITHOUT SIDE EFFECTS. FURTHER STUDIES ON THE LONG-TERM EFFECT OF THIS COMBINATION SHOULD BE ESTABLISHED. |
| Dose amount | VAR |
| Number | 1 |
| Qualitative result | ACTIVE |
| Animal | HUMAN ADULT |
| Dose expression | DOSE |
| Extract | HYDRO-ALCOHOLIC EXT |
| Gender | GIVEN TO BOTH SEXES |