Experiment 626751
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | ORAL |
| Organism | Mentha piperita (LAMIACEAE) |
| Citation | FREISE,J: KOHLER,S:. (1999). PEPPERMINT OIL/CARAWAY OIL-FIXED COMBINATION IN NON-ULCER DYSPEPSIA EQUIVALENT EFFICACY OF THE DRUG COMBINATION IN AN ENTERIC COATED OR ENTERIC SOLUBLE FORMULATION.. 54(3) |
| Amount utilized | |
| Compound isolated | |
| Disease | 223 PATIENTS WITH NON-ULCER DYSPEPSIA (DYSMOTILITY TYPE DYSPEPSIA OR ESSENTIAL/IDIOPATHIC DYSPEPSIA, ALSO IN COMBINATION WITH IRRITABLE BOWEL SYNDROME) WERE INCLUDED IN A PROSPECTIVE, RANDOMISED, REFERENCE- AND DOUBLE-BLIND CONTROLLED MULTI- CENTRE TRAIL TO COMPARED TWO DIFFERENT PREPARATIONS OF A FIXED COMBINATION OF PEPPERMINT OIL AND CARAWAY OIL. THE AIM OF THE TRIAL WAS TO EVALUATE THE EQUIVALENCE OF THE EFFICACY AND TOLERABILITY OF THESE TWO PREPARATIONS. THE TEST FORMULATION CONSISTED OF THE DRUG COMBINATION IN AN ENTERIC COATED CAPSULE CONTAINING 90 MG PEPPERMINT OIL AND 50 MG CARAWAY OIL, WHILE AN ENTERIC SOLUBLE FORMULATION CONTAINING 36 MG PEPPERMINT OIL AND 20 MG CARAWAY OIL WAS USED AS THE REFERENCE. THE MAIN TARGET ITEM DEFINED WAS THE "DIFFERENCE IN PAIN INTENSITY BETWEEN THE BEGINNING AND THE END OF THERAPY", MEASURED BY THE PATIENT ON A VISUAL ANALOGUE SCALE (0 = NO PAIN, 10 = EXTREMELY STRONG PAIN). IN 213 PATIENTS ( N = 108 ON THE TEST PREPARATION GROUP AND 5.9 POINTS IN THE REFERENCE GROUP A STATISTICALLY SIGNIFICANT DECLINE IN PAIN INTENSITY WAS OBSERVED IN THE TWO GROUPS (-3.6 RESP. -3.3 POINTS; P<0.001; TWO-SIDED ONE-SAMPLE T-TEST). |
| Dose amount | VAR |
| Number | 1 |
| Qualitative result | ACTIVE |
| Animal | HUMAN ADULT |
| Dose expression | DOSE |
| Extract | ESSENTIAL OIL |
| Gender | GIVEN TO BOTH SEXES |