| Disease | A RANDOMIZED, DOUBLE-BLIND CROSSOVER TRIAL WAS CONDUCTED IN 51 WOMEN CONSUMING ISOCALORIC SUPPLEMENTS CONTAINING 20 G OF COMPLEX CARBOHYDRATES (COMPARISON DIET), 20 G OF SOY PROTEIN CONTAINING 34 MG OF PHYTOESTROGENS GIVEN IN A SINGLE DOSE, AND
20 G OF SOY PROTEIN CONTAINING 34 MG OF PHYTOESTROGENS SPLIT INTO TWO DOSES. WOMEN WERE RANDOMLY ASSIGNED TO ONE OF THE THREE DIETS FOR 6-WEEK PEROIDS AND SUBSEQUENTLY WERE RANDOMIZED TO THE REMAINING TWO INTERVENTIONS TO DETERMINE WHETHER
DIFFERENCES EXISTED BETWEEN THE TREATMENT DIETS FOR CARDIOVASCULAR DISEASE RISK FACTORS, MENOPAUSAL SYMPTOMS, ADHERENCE, AND POTENTIAL ADVERSE EFFECTS. SIGNIFICANT DECLINES IN TOTAL CHOLESTEROL (6% LOWER) AND LOW DENSITY LIPOPROTEIN CHOLESTEROL
(7% LOWER) WERE OBSERVED IN BOTH SOY DIETS COMPARED WITH THE CARBOHYDRATE PLACEBO DIET. A SIGNIFICANT DECLINE IN DIASTOLIC BLOOD PRESSURE (5 MM HG LOWER) WAS NOTED IN THE TWICE-DAILY SOY DIET, COMPARED WITH THE PLACEBO DIET. ALTHOUGH
NONSIGNIFICANT EFFECTS WERE NOTED FOR A NUMBER OF MEASURES OF QUALITY OF LIFE, A SIGNIFICANT IMPROVEMENT WAS OBSERVED FOR THE SEVERITY OF VASOMOTOR SYMPTOMS AND FOR HYPOESTROGENIC SYMPTOMS IN THE TWICE-DAILY GROUP COMPARED WITH THE PLACEBO GROUP.
NO SIGNIFICANT EFFECTS WERE NOTED FOR TRIGLYCERIDES, HIGH DENSITY LIPOPROTEIN CHOLESTEROL OR FREQUENCY OF MENOPAUSAL SYMPTOMS. SOY SUPPLEMENTATION IN THE DIET OF NONHYPERCHOLESTEROLEMIC, NONHYPERTENSIVE, PERIMENOPAUSAL WOMEN RESULTED IN
SIGNIFICANT IMPROVEMENTS IN LIPID AND LIPOPROTEIN LEVELS, BLOOD PRESSURE, AND PERCEIVED SEVERITY OF VASOMOTOR SYMPTOMS. THESE DATA CORROBORATE THE POTENTIAL IMPORTANCE OF SOY SUPPLEMENTATION IN REDUCING CHRONIC DISEASE RISK IN WESTERN POPULATION |