Experiment 628172

Details

PropertyValue
Pharmacology
Administration routeORAL
OrganismCamellia sinensis (THEACEAE)
CitationTAYLOR,JR: WILT,VM:. (1999). PROBABLE ANTAGONISM OF WARFARIN BY GREEN TEA.. 33(4)
Amount utilized
Compound isolated
DiseaseA 44 YEAR -OLD WHITE MAN WAS RECEIVING WARFARIN FOR THROMBOEMBOLIC PROPHYLAXIS SECONDARY TO A ST JUDE MECHANICAL VALVE REPLACEMENT IN THE AORTIC POSITION. THE PATIENT HAD AN INTERNATIONAL NORMALIZED RATIO (INR) OF 3.20 APPROXIMATELY ONE MONTH PRIOR TO ENTERING OUR CLINIC, AND AN INR OF 3.79 ON ENTERING OUR CLINIC. TWENTY-TWO DAYS LATER HIS INR WAS 1.37. ONE MONTH LATER THE PATIENT'S INR WAS 1.14. IT WAS SUBSEQUENTLY DISCOVERED THAT THE PATIENT BEGAN DRINKING ONE-HALF TO ONE GALLON OF GREEN TEA PER DAY ABOUT ONE WEEK PRIOR TO THE INR OF 1.37. ON DISCONTINUATION OF THE GREEN TEA, THE PATIENT'S INR INCREASED TO 2.55. GREEN TEA CAN BE A SIGNIFICANT SOURCE OF VITAMIN K AND THUS ANTAGONIZE THE EFFECT OF WARFARIN.
Dose amount8.0 L
Number1
Qualitative resultACTIVE
AnimalHUMAN ADULT
Per unitDAY
Dose expressionDOSE
ExtractH2O EXT
GenderMALE