Experiment 634056
Worktypes
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | SC |
| Organism | Echinacea purpurea (ASTERACEAE) |
| Citation | COEUGJNIET,E:. (1986). RECURRENT CANDIDIASIS.. 36() |
| Amount utilized | |
| Compound isolated | |
| Disease | BY A COMPARATIVE STUDY, THE INFLUENCE OF AN ECHINACEA PURPUREA EXTRACT (ECHINACIN) WAS EXAMINED AS AN IMMUNOSTIMULATING AGENT IN ORDER TO TEST THE FREQUENCY OF RECIDIVES OF CANDIDAL MYCOSIS. IN ALL CASES ECONAZOLE NITRATE CREAM HAS BEEN APPLIED FOR LOCAL TREATMENT ABOUT SIX DAYS. IN ADDITION TO THAT THE CELL MEDIATED IMMUNITY HAS BEEN INQUIRED BY MEANS OF A CUTANEOUS TEST (MULTITEST MERIEUX). THIS HAPPENS BEFORE THE THERAPY HAS BEEN STARTED AND ALSO TWO AND TEN WEEKS LATER. THIS TEST REVEALED SCORE-VALUES OF ABOUT 5 MM (SO CALLED ALARM SCORE) BEFORE TREATMENT. AN UNSPECIFIC IMMUNOTHERAPY WITH ECHINACIN AMPOULES (IM, IV, SC) WAS ADDITIONALLY APPLIED TO LOCAL THERAPY AND IMPROVED THE SKIN REACTION SIGNIFICANTLY WITHIN 2 WEEKS. THE SECOND CONTROL TEN WEEKS AFTER STARTING THE TREATMENT SHOWED A STATISTICALLY SIGNIFICANT NORMALISATION OF CELL-MEDIATED IMMUNITY TOO; ALSO IN PATIENTS WHO HAVE BEEN TREATED ORALLY BY ECHINACIN DROPS. THE FREQUENCY OF RECURRENCE RATE IN PATIENTS WHO WERE TREATED LOCALLY BY ECONAZOLE NITRATE WAS VERY HIGH (60.5%), BUT IT REDUCED THIS RATE BY VALUES BETWEEN 5% AND 16% (ACCORDING TO THE FORM OF APPLICATION) IN PATIENTS TREATED BY UNSPECIFIC IMMUNOSTIMULATION WITH ECHINACIN. A COMMERCIAL PRODUCT, ECHINACIN, WAS USED. |
| Dose amount | 2.0 ML |
| Number | 3 |
| Qualitative result | ACTIVE |
| Animal | HUMAN ADULT |
| Per unit | DAY |
| Dose expression | DOSE |
| Extract | POLYSACCHARIDE FRACTION |
| Gender | GIVEN TO BOTH SEXES |