| Disease | THE EFFECTS OF 60 AND 120 MG VALERIAN HAVE BEEN INVESTIGATED BY COMPUTER ANALYSIS OF SLEEP STAGES (SLEEP PROFILES) AND PSYCHOMETRIC METHODS (QUESTIONAIRES). EOG, EMG OF CERVICAL MUSCLES, ECG AND EEG (TWO-SIDED: CENTRO-OCCIPITAL AND FRONTO-
CENTRAL) HAVE BEEN RECORDED FROM 6 MALE AND 5 FEMALE HEALTHY VOLUNTEERS. AMPLIFIED SIGNALS HAVE BEEN ANALYSED ON-LIN (POWER SPECTRAL ANALYSIS) AND THE SLEEP PROFILES HAVE BEEN CALCULATED ACCORDINGLY. AFTER ONE NIGHT FOR ADAPTATION, EACH SUBJECT
TOOK ORALLY PLACEBO, 60 AND 120 MG VLAERIAN (1 RESP. 2 CAPSULES HARMONICUM MUCH) ACCORDING TO A RANDOMIZED DOUBLE-BLIND REPEATED MEASURES-DESIGN. THE SLEEP INVESTIGATIONS HAVE BEEN CARRIED OUT BY DISTANCE OF A WEEK FOR EACH CONDITION (DOSAGE PER
SUBJECT). IN THE MORNING FOLLOWING THIS NIGHT, THE SUBJECTS COMPLETED A MOOD SCALE. BOTH DOSAGES SHOWED A DECREASE OF SLEEP STAGE 4 AND A SLIGHT REDUCTION OF REM-SLEEP. IN CONTRAST, A SLIGHT INCREASE OF SLEEP STAGE AWAKE, 1 AND 2 COULD BE
OBSERVED. A FURTHER INCREASE OF SLEEP STAGE 3 COULD BE IDENTIFIED. AFTER APPLICATION OF 120 MG VALERIAN, THE FREQUENCY OF REM-PHASES (IN %) DECLINED DURING THE FIRST HALF OF THE NIGHT, WHEREAS DURING THE SECOND PART OF THE NIGHT, A SURPLUS
APPEARED. CHANGES OF THE BETA-INTENSITY OF THE EEG DURING REM-SLEEP SHOW A STRONGER HYPNOTIC EFFECT FOR THE 120 MG DOSAGE THAN FOR 60 MG. MAXIMUM EFFECT WAS OBSERVED BETWEEN 2 AND 3 HOURS POST MEDICATION.
A COMMERCIAL PRODUCT, HARMONICUM MUCH, WAS USED. |