Experiment 634074
Worktypes
Compounds isolated
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | INHALATION |
| Organism | Empty organism |
| Citation | ECCLES,R: GRIFFITHS,DH: NEWTON,CG: TOLLEY,NS:. (1988). THE EFFECTS OF MENTHOL ISOMERS ON NASAL SENSATION OF AIRFLOW.. 1988(13) |
| Amount utilized | |
| Compound isolated | |
| Disease | THE EFFECTS OF INHALATION OF L-MENTHOL, D-ISOMENTHOL AND D-NEOMENTHOL, UPON NASAL RESISTANCE AND SENSATION TO ARIFLOW WERE INVESTIGATED IN 40 SUBJECTS. L-MENTHOL CAUSED A HIGHLY SIGNIFICANT ENHANCEMENT OF NASAL SENSATION OF AIRFLOW BUT DESPITE THEIR GREAT SIMILARILY IN STRUCTURE AND A SIMILAR PEPPERMINT SMELL THE ISOMERS D-ISOMENTHOL AND D-NEOMENTHOL HAD NO EFFECT ON NASAL SENSATION OF AIRFLOW. THESE FINDINGS SHOW THAT L-MENTHOL HAS A SPECIFIC PHARMACOLOGICAL ACTION ON NASAL SENSORY NERVE ENDINGS WHICH IS NOT RELATED TO ITS PEPPERMINT SMELL. |
| Number | 1 |
| Qualitative result | ACTIVE |
| Animal | HUMAN ADULT |
| Dose expression | DOSE |
| Gender | GIVEN TO BOTH SEXES |