Experiment 634970
Worktypes
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | INTRAGASTRIC |
| Organism | Ginkgo biloba (GINKGOACEAE) |
| Citation | BIBER,A: KOCH,E:. (1999). BIOAVAILABILITY OF GINKGOLIDES AND BILOBALIDE FROM EXTRACTS OF GINKGO BILOBA USING GC/MS.. 65(2) |
| Amount utilized | |
| Compound isolated | |
| Disease | THE BIOAVAILABILITY OF GINKGOLIDES A, B AND BILOBALIDE WAS STUDIED IN RATS AFTER SINGLE ORAL IDMINISTRATION OF 30, 55 AND 100 MG/KG GINKGO EXTRACT EGB 761. THE PLASMA LEVELS OF THE TERPENE LACTONES WERE MEASURED BY A SPECIFIC GC/MS METHOD. THE PHARMACOKINETICS OF THE MENTIONED SUBSTANCES WERE FOUND TO BE DOSE-LINEAR. FOR THE LOWEST DOSE MAXIMUM CONCENTRATIONS WERE 68, 40 AND 159 MG/ML AND HALF-LIVES 1.7, 2.0 AND 2.2 H FOR GINKGOLIDE A, B AND BILOBALIDE, RESPECTIVELY, CLEARANCE VALUES RANGED FROM 24.2 TO 37.6 ML/MIN/KG. A COMMERCIAL PRODUCT, EGB-761, WAS USED. |
| Dose amount | VAR |
| Number | 1 |
| Qualitative result | . |
| Animal | RAT |
| Dose expression | DOSE |
| Extract | ETOH(100%)EXT |
| Gender | MALE |