Experiment 635000

Worktypes

Details

PropertyValue
Pharmacology
Administration routeIV
OrganismGinkgo biloba (GINKGOACEAE)
CitationVAVRINA,J: MULLER,W:. (1995). THERAPEUTIC EFFECT OF HYPERBARIC OXYGENATION IN ACUTE ACOUSTIC TRAUMA.. 116(5)
Amount utilized
Compound isolated
DiseaseRETROSPECTIVELY 78 PATIENTS WITH UNI-OR BILATERAL ACUTE ACOUSTIC TRAUMA (AAT) WERE EVALUATED TO ASSESS THE THERAPEUTIC EFFECT OF HYPERBARIC OXYGENATION (HBO). ALL SUBJECTS RECEIVED SALINE OR DEXTRAN (RHEOMACODREX) INFUSIONS WITH GINKGO EXTRACTS (TEBONIN) AND PREDNISONE, 36 PATIENTS UNDERWENT ADDITIONAL HYPERBARIC OXYGENATION AT A PRESSURE OF 2 ATMOSPHERES FOR 60 MINUTES ONCE DAILY. BOTH TREATMENT GROUPS WERE COMPARABLE AS FAR AS AGE, GENDER, INITIAL HEARING LOSS AND PREDNISONE DOSE ARE CONCERNED. THE DELAY OF THERAPY ONSET WAS 15 HOURS IN BOTH GROUPS AND TREATMENT WAS STARTED WITHIN 72 HOURS IN ALL CASES. CONTROL AUDIOMETRY WAS PERFORMED AFTER 6.5 DAYS, WHEN THE HBO GROUP HAD HAD 5 EXPOSURES TO HYPERBARIC OXYGENATION. THE AVERAGE HEARING GAIN IN THE GROUP WITHOUT HBO WAS 74.3 DB AND IN THE GROUP TREATED ADDITIONALLY WITH HBO WAS 121.3 DB (P<0.004). IT IS CONCLUDED, THAT HYPERBARIC OXYGENATION SIGNIFICANTLY IMPROVES HEARING RECOVERY AFTER AAT. A COMMERCIAL PRODUCT, TEBONIN, WAS USED.
Number1
Qualitative resultACTIVE
AnimalHUMAN ADULT
Dose expressionDOSE
ExtractETOH(100%)EXT
GenderGIVEN TO BOTH SEXES