Experiment 635002

Worktypes

Details

PropertyValue
Pharmacology
Administration routeORAL
OrganismGinkgo biloba (GINKGOACEAE)
CitationSEMLITSCH,HV: ANDERER,P: SALETU,B: BINDER,GA: DECKER,KA:. (1995). COGNITIVE PSYCHOPHYSIOLOGY IN NOOTROPIC DRUG RESEARCH: EFFECTS OF GINKGO BILOBA ON EVENT-RELATED POTENTIALS (P300) IN AGE-ASSOCIATED MEMORY IMPAIRMENT.. 28()
Amount utilized
Compound isolated
DiseaseTHE EFFECTS OF GINKGO-BILOBA EXTRACT GINKOBENE ON COGNITIVE INFORMATION-PROCESSING WERE INVESTIGATED BY MEANS OF LONG-LATENCY AUDITORY EVENT-RELATED POTENTIALS. IN A DOUBLE-BLIND PLACEBO-CONTROLLED STUDY, 48 PATIENTS (29 WOMEN AND 19 MEN) AGED BETWEEN 51 AND 79 YEARS WITH THE DIAGNOSIS OF AGE-ASSOCIATED MEMORY IMPAIRMENT HAD 57 DAYS TREATMENT WITH A DAILY DOSAGE OF 3 X 40 MG GINKOBENE OR PLACEBO. TO EVALUATE ACUTE, CHRONIC, AND SUPERIMPOSED DRUG EFFECTS, PSYCHOPHYSIOLOGICAL INVESTIGATIONS WERE CARRIED OUT ON DAY 1 AND DAY 57 BEFORE AND 3 HOURS WHEN COMPARED TO THE PLACEBO GROUP, IN THE GINKOBENE GROUP NO CONSISTENT AND UNEQUIVOCAL CHANGES ON N1,P2,N2, AND P300 AMPLITUDES OR ON N1,P2,AND N2 LATENCIES WERE OBSERVED P300 LATENCY WAS SHORTENED BY 31 MS,38 MS, AND 32 MS IN THE GINKGO BILOBA GROUP AFTER ACUTE, CHRONIC, AND SUPERIMPOSED DRUG ADMINISTRATION. IT MAY THEREFORE BE HYPOTHESIZED THAT THE DECREASE OF P300 LATENCY IN THE GINKGO BILOBA GROUP MAY REFLECT SHORTER STIMULUS-EVALUATION TIME. AS THIS EFFECT WAS NOT ACCOMPANIED BY POSITIVE EFFECTS ON SUBJECTIVE WELL-BEING, IT MAY BE CONCLUDED THAT IT IS NOT MEDIATED BY THYMOPSYCHIC ALTERATIONS. A COMMERCIAL PRODUCT, GINKGOBENE, WAS USED.
Dose amount120.0 MG
Number1
Qualitative resultACTIVE
AnimalHUMAN ADULT
Per unitDAY
Dose expressionDOSE
ExtractTYPE EXT NOT STATED
GenderGIVEN TO BOTH SEXES