Experiment 635008
Worktypes
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | ORAL |
| Organism | Hypericum perforatum (CLUSIACEAE) |
| Citation | SCHEMPP,CM: WINGHOFER,B: LANGHEINRICH,M: SCHOPF,E: SIMON,JC:. (1999). HYPERICIN LEVELS IN HUMAN SERUM AND INTERSTITIAL SKIN BLISTER FLUID AFTER ORAL SINGLE-DOSE AND STEADY-STATE ADMINISTRATION OF HYPERICUM PERFORATUM EXTRACT (ST.JOHN'S WORT).. 12(5) |
| Amount utilized | |
| Compound isolated | |
| Disease | A STUDY WITH 12 HEALTHY HUMAN VOLUNTEERS WAS CONDUCTED TO MEASURE HYPERICIN LEVELS IN HUMAN SERUM AND INTERSTITIAL SKIN BLISTER FLUID AFTER ORAL SINGLE DOSE AND STEADY-STATE ADMINISTRATION OF HYPERICUM. SERUM LEVELS OF HYPERICIN AND PSEUDOHYPERICIN WERE ALWAYS SIGNIFICANTLY HIGHER THAN SKIN LEVELS (P<0.01). HYPERICIN WAS DETECTED IN HUMAN SKIN BLISTER FLUID, BUT THE AMOUNT WAS FAR BELOW HYPERICIN SKIN LEVELS THAT ARE ESTIMATED TO BE PHOTOTOXIC. A COMMERCIAL PRODUCT, LI-160, WAS USED. |
| Dose amount | VAR MG |
| Number | 1 |
| Qualitative result | ACTIVE |
| Animal | HUMAN ADULT |
| Dose expression | DOSE |
| Extract | HYDRO-ALCOHOLIC EXT |