Experiment 635038

Worktypes

Details

PropertyValue
Pharmacology
Administration routeORAL
OrganismHypericum perforatum (CLUSIACEAE)
CitationJOHHNSON,D: SIEBENHUNER,G: HOFER,E: SAUERQEIN-GIESE,E: FRAUENDORF,A:. (1992). INFLUENCE OF ST.JOHN'S WORT ON CNS ACTIVITY.. 6()
Amount utilized
Compound isolated
DiseaseTHE NEUROPHYSIOLOGICAL ACTION PROFILE (EVOKED POTENTIALS, QUANTITATIVE EEG) OF HYPERICUM EXTRACT LI 160 AND ITS EFFECTS ON SUBJECTIVE WELL-BEING AND ON COGNITIVE PERFORMANCE PARAMETERS WERE INVESTIGATED IN A PLACEBO-CONTROLLED DOUBLE-BLIND STUDY. THE ACTION OF HYPERICUM EXTRACT LI 160 CORRESPONDS TO THAT OF AN ANTIDEPRESSANT OF AVERAGE EFFICACY, BOTH ACUTE AND CHRONIC NEUROPHYSIOLOGICAL EFFECT BEING OBSERVED. THE INCREASE IN COGNITIVE ACTIVITY IS REFLECTED BY THE SMALLER NUMBER OF ERRORS MADE IN MACKWORTH CLOCK TEST. NO ADVERSE DRUG REACTIONS OCCURRED DURING THE 6 WEEKS OF TREATMENT WITH LI 101. HYPERICUM EXTRACT LI 160 HAD A PREDOMINANTLY ACTIVATING INFLUENCE ON THE VISUAL AND ACOUSTIC SYSTEM ALSO, SHOWED A RESTING EEG PROFILE TYPICAL OF AN ANTIDEPRESSANT. ALSO IN THE VIGILANCE TEST, THE VOLUNTEER MADE FEWER MISTAKSE AFTER TAKING LI 160 THAN UNDER PLACEBO. A COMMERCIAL PRODUCT, LI-160, WAS USED.
Dose amount900.0 MG
Number1
Qualitative resultACTIVE
AnimalHUMAN ADULT
Per unitDAY
Dose expressionDOSE
ExtractHYDRO-ALCOHOLIC EXT
GenderGIVEN TO BOTH SEXES