Experiment 635088
Worktypes
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | ORAL |
| Organism | Piper methysticum (PIPERACEAE) |
| Citation | PEPPING,J:. (1999). KAVA: PIPER METHYSTICUM.. 56(10) |
| Amount utilized | |
| Compound isolated | |
| Disease | THE ABSORPTION AND BIOAVAILABILITY OF THE RAW EXTRACT SEEM SUPERIOR TO THOSE OF PURIFIED KAVALACTONES. PEAK PLASMA LEVELS OCCUR ABOUT 1.8 HOURS AFTER AN ORAL DOSE. THE HALF-LIFE OF KAVALACTONES IS APPROXIMATELY NINE HOURS. ELIMINATION SEEMS TO OCCUR PRIMARILY VIA RENAL EXCRETION (BOTH UNCHANGED KAVALACTONES AND METABOLITES) AND THE FECES. METABOLIC TRANSFORMATIONS INCLUDED REDUCTION OR DEMETHYLATION OF THE A-PYRONE RING SYSTEM; HOWEVER, THE EXTENT OF METABOLIC TRANSFROMTION HAS BEEN REPORTED. |
| Dose amount | 750.0 MG |
| Number | 1 |
| Qualitative result | ACTIVE |
| Animal | HUMAN ADULT |
| Per unit | DAY |
| Dose expression | DOSE |
| Extract | HYDRO-ALCOHOLIC EXT |
| Gender | GIVEN TO BOTH SEXES |