Experiment 635093

Compounds isolated

Details

PropertyValue
Pharmacology
Administration routeOPHTHALMIC
OrganismEmpty organism
CitationMOHAN,M: PANT,CR: ANGRA,SK: MAHAJAN,VM:. (1982). BERBERINE IN TRACHOMA.. 1982(30)
Amount utilized
Compound isolated
DiseaseA CLINICAL STUDY WAS CONDUCTED IN PRIMARY SCHOOL CHILDREN WHO WERE SUFFERING FROM TRACHOMA. 96 CASES WERE SELECTED FOR A MASKED STUDY. CLINICAL PARMETERS OF THESE CASES WERE RECORDED. PATINENTS WERE ADVISED TO INSTALL THE DROPS 3 TIMES A DAY AND OINTMENT AT BED TIME IN BOTH THE EYES FOR PERIOD OF 3 MONTHS. THE DRUGS USED WERE: I) 0.2% BERBERINE DROPS AND OINTMENT. II) 0.2% BERBERINE DROPS WITH 0.5% NEOMYCIN AND OINTMENT. III) 20% SODIUM FULFACETOMIDE DROPS AND 6% SODIUM SULFACETAMIDE OINTMENT. IV) PLACEBO DROPS (NORMAL SALINE) AND PLACEBO OINTMENT (PARAFFIN BASE). STUDY SHOWED THAT 83.88% WERE CURED CLINICALLY AND ONLY 50% BECAME MICROBIOLOGICALLY NEGATIVE WHEN THEY WERE TREATED WITH BERBERINE ALONE. RESPONSE RATES WERE HIGHER, 87.5% AND 58.83% IN THOSE TREATED WITH BERBERINE AND NEOMYCIN AND LOWER WITH SULFACETAMIDE, 72.72% AND 40.9% RESPECTIVELY.
Dose amountVAR
Number1
Qualitative resultACTIVE
AnimalHUMAN CHILD
Dose expressionDOSE