Experiment 635110
Worktypes
Compounds isolated
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | ORAL |
| Organism | Empty organism |
| Citation | ZHANG,YW: WANG,YF: LI,CJ: ZHOU,J: ZHANG,DY: HAN,ML:. (1996). ESTROGEN AND PROGESTIN CYTOSOL RECEPTOR CONCENTRATIONS IN PATIENTS WITH ENDOMETRIOSIS AND THEIR CHANGES AFTER GOSSYPOL THERAPY.. 109(10) |
| Amount utilized | |
| Compound isolated | |
| Disease | 31 PATIENTS WITH ENDOMETROSIS (EM) WERE GIVEN GOSSYPOL TO INVESTIGATE THE ESTROGEN AND PROGESTIN CYTOSOL RECEPTOR CONCENTRATION OF UTERINE AND ECTOPIC ENDOMETRIUM AND TO EXPLORE THE MECHANISM OF ACTION OF GOSSYPOL BY COMPARING SERUM ESTRODIOL AND PROGESTRONE/ ENDOMETRIAL BIOPSICS WERE PERFORMED IN DIFFERENT PHASE OF MENSTRUAL CYCLE ON 24 EM PATIENTS AND THE 27 CONTROLS. AND ESTROGEN RECEPTOR AND PROGESTRON RECEPTORS WERE DETERMINED. 15 PATIENTS WERE GIVEN GOSSYPOL FOR 2 MONTHS. AND 16 HAD SURGERY. STUDY SHOWED THAT AFTER 2 MONTHS GOSSYPOL TREATMENT, SERUM ESTROGEN AND PROGESTRONE CONCENTRATIONS AND ENDOMETRIUM HISTOLOGY DID NOT SHOW SIGNIFICANT CHANGES. HOWEVER ESTROGEN RECEPTOR AND PROGESTERONE RECEPTOR CONTENTS OF ENDOMETRIUM DROPPED BY 50% AND MORE. THE ATROPHIC EFFECT OF GOSSYPOL ON ENDOMETRIUM MAY BE ASSOCIATED WITH INHIBITION OF SEX STEROID HORMONE RECEPTOR SYNTHESIS. |
| Dose amount | 20.0 MG |
| Number | 1 |
| Qualitative result | ACTIVE |
| Animal | HUMAN ADULT |
| Per unit | DAY |
| Dose expression | DOSE |
| Gender | FEMALE |