Experiment 635121
Worktypes
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | EXTERNAL |
| Organism | Oenothera biennis (ONAGRACEAE) |
| Citation | GEHRING,W: BOPP,R: RIPPKE,F: GLOOR,M:. (1999). EFFECT OF TOPICALLY APPLIED EVENING PRIMROSE OIL ON EPIDERMAL BARRIER FUNCTION IN ATOPIC DERMATITIS AS A FUNCTION OF VEHICLE.. 49(11) |
| Amount utilized | |
| Compound isolated | |
| Disease | STUDY TO ESTABLISH THE EFFECT ON BARRIER FUNCTION IN ATOPIC DERMATITIS OF TOPICAL EVENING PRIMROSE OIL IN A AMPHIPHILIC AND A STABLE WATER-IN-OIL EMULSION. THE STUDIES WERE VEHICLE-CONTROLLED IN TWO POPULATIONS OF 20 ATOPIC SUBJECTS. BARRIER FUNCTION WAS ASSESSED IN TERMS OF TRANSEPIDERMAL WATER LOSS AND STRATUM CORNEUM HYDRATION AFTER A 4-WEEK TREATMENT PERIOD AND A 1-WEEK TREATMENT-FREE PERIOD. EVENING PRIMROSE OIL PROVED TO HAVE A STABILISING EFFECT ON THE STRATUM CORNEUM BARRIER, BUT THIS WAS APPARENT ONLY WITH THE WATER-IN-OIL EMULSION, NOT THE AMPHIPHILIC EMULSION. THE CHOICE OF VEHICLE IS THEREFORE AN EXTREMELY IMPORTANT FACTOR IN THE EFFICACY OF TOPICALLY APPLIED EVENING PRIMROSE OIL. |
| Dose amount | 2.0 ML |
| Number | 1 |
| Qualitative result | ACTIVE |
| Animal | HUMAN ADULT |
| Per unit | DAY |
| Dose expression | DOSE |
| Extract | FIXED OIL |
| Gender | GIVEN TO BOTH SEXES |