Experiment 635126
Worktypes
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | ORAL |
| Organism | Citrus paradisi (RUTACEAE) |
| Citation | VAN AGTMAEL,MA: GUPTA,V: VAN DER WOSTEN,TH: RUTTEN,JPB: VAN BOXTEL,CJ:. (1999). GRAPEFRUIT JUICE INCREASES THE BIOAVIALABILITY OF ARTEMETHER.. 55(5) |
| Amount utilized | |
| Compound isolated | |
| Disease | SIX HEALTHY MALE SUBJECTS WERE GIVEN A STANDARD BREAKFAST FOLLOWED BY TWO TABLETS OF 50-MG ARTEMETHER ADMINISTERED WITH WATER; 1 WEEK LATER, THE TABLETS WERE ADMINISTERED WITH 350 ML DOUBLE-STRENGTH FRESH FROZEN GRAPEFRUIT JUICE. FOR 8 H. 17 BLOOD-AND SALIVA SAMPLES WERE COLLECTED, AND 17 ELECTROCARDIOGRAMS WERE RECORDED. DRUG AND METABOLITE CONCENTRATIONS WERE MEASURED BY MEANS OF HIGH-PERFORMANCE LIQUID CHROMATOGRAPHY WITH ELECTROCHEMICAL DETECTION. THE PHARMACOKINETIC PARAMETERS WERE DETERMINED USING A ONE-COMPARTMENT MODEL. GRAPEFRUIT JUICE SIGNIFICANTLY (P=0.001) INCREASED THE MEAN PEAK CONCENTRATION OF ARTEMETHER MORE THAN TWOFOLD. GRAPEFRUIT JUICE SIGNIFICANTLY INCREASES THE ORAL BIOAVAILABILITY OF ARTEMETHER WITH OUT AN EFFECT ON THE ELIMINATION HALF-LIFE. |
| Dose amount | 350.0 ML |
| Number | 1 |
| Qualitative result | ACTIVE |
| Animal | HUMAN ADULT |
| Per unit | DAY |
| Dose expression | DOSE |
| Extract | FRUIT JUICE |
| Gender | MALE |