Experiment 635135
Worktypes
Compounds isolated
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | ORAL |
| Organism | Empty organism |
| Citation | JACOB,S: RUUS,P: HERMANN,R: TRITSCHLER,HJ: MAERKER,E: RENN,W: AUGUSTIN,HJ: DIETZE,GJ: RETT,K:. (1999). ORAL ADMINISTRATION OF RAC-ALPHA-LIPOIC ACID MODULATES INSULIN SENSITIVITY IN PATIENTS WITH TYPE-2 DIABETES MELLITUS: A PLACEBO-CONTROLLED PILOT TRIAL.. 27(3/4) |
| Amount utilized | |
| Compound isolated | |
| Disease | CLINICAL STUDIES DESCRIBED AN INCREASE OF INSULIN SENSITIVITY AFTER ACUTE AND SHORT-TERM(10D) PARENTERAL ADMINISTRATION OF ALA. THE EFFECTS OF A 4-WEEK ORAL TREATMENT WITH ALPHA-LIPOIC ACID WERE EVALUATED IN PLACEBO-CONTROLLED. MULTICENTER PILOT STUDY TO DETERMINE SEE WHETHER ORAL TREATMENT ALSO IMPROVES INSULIN SENSITIVITY. SEVENTY-FOUR PATIENTS WITH TYPE-2 DIABETES WERE RANDOMIZED TO EITHER PLACEBO(N=19); OR ACTIVE TREATMENT IN VARIOUS DOSES OF 600 MG ONCE DAILY(N=19), TWICE DAILY (1200MG; N=18), OR THRICE DAILY(1800 MG; N=18) ALPHA-LIPOIC ACID. AN ISOGLYCEMIC GLUCOSE-CLAMP WAS DONE ON DAYS 0 (PRE) AND 29 (POST).IN THIS EXPLORATIVE STUDY, ANALYSIS WAS DONE ACCORDING TO THE NUMBER OF SUBJECTS SHOWING AND IMPROVEMENT OF INSULIN SENSITIVITY AFTER TREATMENT. FURTHERMORE, THE EFFECTS OF ACTIVE VS.PLACEBO TREATMENT ON INSULIN SENSITIVITY WAS COMPARED. ALL FOUR GROUPS WERE COMAPARABLE AND HAD A SIMILAR DEGREE OF HYPERGLYCEMIA AND INSULIN SENSITIVITY AT BASELINE. WHENCOMPARED TO PLACEBO, SIGNIFICANTLY MORE SUBJECTS HAD AN INCREASE IN INSULIN-STIMULATED GLUCOSE DISPOSAL(MCR) AFTER ALA TREATMENT IN EACH GROUP. AS THERE WAS NO DOSE EFFECT SEEN IN THE THREE DIFFERENT ALPHA-LIPOIC ACID GROUPS, ALL SUBJECTS RECEIVING ALA WERE COMBINED IN THE "ACTIVE" GROUP AND THEN COMPARED TO PLACEBO. THIS REVEALED SIGNIFICANTLY DIFFERENT CHANGES IN MCR AFTER TREATMENT(+27% VS.PLACEBO;P<.01). THIS PLACEBO-CONTROLLED EXPLORATIVE STUDY CONFIRMS PREVIOUS OBSERVATIONS OF AN INCREASE OF INSULIN SENSITIVITY IN TYPE-2 DIABETES AFTER ACUTE AND CHRONIC INTRAVENOUS ADMINISTRATION OF ALA. THE RESULTS SUGGEST THAT ORAL ADMINISTRATION OF ALPHA-LIPOIC ACID CAN IMPROVE INSULIN SENSITIVITY IN PATIENTS WITH TYPE-2 DIABETES. THE ENCOURAGING FINDINGS OF THIS PILOT TRIAL NEED TO BE SUBSTANTIATED BY FURTHER INVESTIGATIONS. |
| Dose amount | VAR |
| Number | 1 |
| Qualitative result | ACTIVE |
| Animal | HUMAN ADULT |
| Dose expression | DOSE |
| Gender | GIVEN TO BOTH SEXES |