Experiment 635147
Worktypes
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | ORAL |
| Organism | Silybum marianum (ASTERACEAE) |
| Citation | PEPPING,J:. (1999). MILK THISTLE: SILYBUM MARIANUM.. 56(12) |
| Amount utilized | |
| Compound isolated | |
| Disease | A RANDOMIZED TRIAL SILYMARIN 420 MG/DAY VERSUS PLACEBO WAS CONDUCTED IN 106 PATIENTS WITH MILD ALCOHOLIC LIVER DISEASE (CONCENTRATIONS OF ALT AND AST, <200 UNITS/L) AND PERSISTENT LIVER-FUNCTION ABNORMALITIES AFTER ABSTINENCE FROM ALCOHOL FOR AT LEAST 1 MONTH. AT THE END OF THE 4-WEEK STUDY, MEAN AST AND ALT LEVELS HAD DECLINED BY 30.1% AND 40.8%, RESPECTIVELY, IN THE 47 SILYMARIN-TREATED PATIENTS WHO COMPLETED THE STUDY, COMPARED WITH INCREASES OF 5.4% AND 2.8%, RESPECTIVELY, IN THE 50 PLACEBO-GROUP PATIENTS WHO COMPLETED THE STUDY (P<0.001). NO SIGNIFICANT DIFFERENCE IN BILIRUBIN LEVELS WAS OBSERVED BETWEEN THE TWO GROUPS. |
| Dose amount | 420.0 MG |
| Number | 4 |
| Qualitative result | ACTIVE |
| Animal | HUMAN ADULT |
| Per unit | DAY |
| Dose expression | DOSE |
| Extract | HYDRO-ALCOHOLIC EXT |