Experiment 635149
Worktypes
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | ORAL |
| Organism | Silybum marianum (ASTERACEAE) |
| Citation | PEPPING,J:. (1999). MILK THISTLE: SILYBUM MARIANUM.. 56(12) |
| Amount utilized | |
| Compound isolated | |
| Disease | INDICATED THAT TREATMENT WAS MOST EFFECTIVE IN PATIENTS WITH ALCOHOLIC CIRRHOSIS (P=0.01) AND CHILD'S GROUP A CLASSIFICATION OF PORTAL HYPERTENSION (NONALCOHOLIC CIRRHOSIS) AND WAS INEFFECTIVE IN PATIENTS WITH CHILD'S GROUPS B AND C HYPERTENSION 170 PATINETS WITH BIOPSY-CONFIRMED CIRRHOSIS WEE OBSERVED FOR 2 TO 6 YEARS (MEAN,41 MONTHS). 87 PATIENTS (46 WITH ALCOHOL-RELATED CIRRHOSIS) RECEIVED 140 MG OF SILYMARIN ORALLY 3X DAILY, AND 83 PATIENTS(45 WTH ALCOHOL RELATEDCIRRHOSIS) RECEIVED PLACEBO. IN THE 105 PATIENTS WHO PARTICIPATED IN THE STUDY FOR AT LEAST 2 YEARS, BIOCHEMICAL MARKERS DID NOT CHANGE SIGNIFICANTLY; HOWEVER, THE 4-YEAR MEAN S.E. SURVIVAL RATE WAS 58_ 9% IN THE SILYMARIN-TREATED GROUP (P=0.036). SUBGROUP ANALYSIS |
| Dose amount | 420.0 MG |
| Number | 6 |
| Qualitative result | ACTIVE |
| Animal | HUMAN ADULT |
| Per unit | DAY |
| Dose expression | DOSE |
| Extract | HYDRO-ALCOHOLIC EXT |