Experiment 635150
Worktypes
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | ORAL |
| Organism | Silybum marianum (ASTERACEAE) |
| Citation | PEPPING,J:. (1999). MILK THISTLE: SILYBUM MARIANUM.. 56(12) |
| Amount utilized | |
| Compound isolated | |
| Disease | DOUBLE-BLIND STUDIES IN PATIENTS WITH ACUTE VIRAL HEPATITIS GENERALLY SUGGEST THAT THERAPY WITH SILYMARIN DECREASES COMPLICATIONS, HASTENS RECOVERY, AND SHORTENS HOSPITALIZATION. IN A STUDY BY MAGLIULO ET AL., 57 PATIENTS WITH ACUTE HEPATITIS A OR B WERE RANDOMIZED TO RECEIVE 140 MG OF SILYMARIN 3X A DAY FOR AT LEAST THREE WEEKS OF PLACEBO. UNDERLYING LIVER DISEASE AND ALCOHOL USE WERE NOT ADDRESSED IN THE STUDY. THE MEAN DURATION OF THERAPY WAS 26.6 DAYS. THE PERCENTAGE OF PATIENTS WITH NORMALIZATION OF ASPARTATE TRANSAMINASE (AST) CONCENTRATION WITHIN 3 WEEKS WAS 82% IN THE TREATMENT GROUP, VERSUS 52% IN THE CONTROL GROUP. THE PERCENTAGE WITH NORMALIZED TOTAL BILIRUBIN WAS 40% IN THE TREATMENT GROUP AND 11% AMONG THE CONTROLS. |
| Dose amount | 420.0 MG |
| Number | 7 |
| Qualitative result | ACTIVE |
| Animal | HUMAN ADULT |
| Per unit | DAY |
| Dose expression | DOSE |
| Extract | HYDRO-ALCOHOLIC EXT |