Experiment 635152
Worktypes
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | ORAL |
| Organism | Silybum marianum (ASTERACEAE) |
| Citation | PEPPING,J:. (1999). MILK THISTLE: SILYBUM MARIANUM.. 56(12) |
| Amount utilized | |
| Compound isolated | |
| Disease | CLINICAL STUDIES HAVE SHOWN MILK THISTLE EXTRACT TO HAVE AN EXCELLENT SAFETY PROFILE AND THERAPEUTIC DOSAGES. SILYMARIN HAS CHOLERETIC ACTIVITY, AND HIGH DOSAGES (>1500 MG/DAY) MAY PRODUCE LOOSE STOOLS BECAUSE OF INCREASED BILE FLOW AND SECRETION. IT WOULD BE REASONABLE TO ASSUME THAT IRRITATION OF THE GASTRIC MUCOSA COULD OCCUR IN PATIENTS WITH INFLAMMATORY OR IRRITABLE BOWEL DISORDERS. A RECENT CASE REPORT FROM AUSTRALIA DESCRIBED A REACTION TO MILK THISTLE EXTRACT THAT INCLUDED INTERMITTENT EPISODES OF SEVERE SWEATING, ABDOMINAL CRAMPING, NAUSEA, VOMITING, DIARRHEA, AND WEAKNESS. ADVERSE EFFECTS WERE VERIFIED BY RECHALLENGE. THE AUTHORS NOTED THAT IT WAS POSSIBLE THAT THE REACTION WAS DUE TO SOME SUBSTANCE IN THE PRODUCT OTHER THAN SILYBIN. |
| Dose amount | 1.50 GM |
| Number | 9 |
| Qualitative result | INACTIVE |
| Animal | HUMAN ADULT |
| Per unit | DAY |
| Dose expression | DOSE |
| Extract | HYDRO-ALCOHOLIC EXT |