Experiment 635155
Worktypes
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | ORAL |
| Organism | Hypericum perforatum (CLUSIACEAE) |
| Citation | KIM,KL: STRELTZER,J: GOEBERT,D:. (1999). ST. JOHN'S WORT FOR DEPRESSION. A META-ANALYSIS OF WELL-DEFINED CLINICAL TRIALS.. 187(9) |
| Amount utilized | |
| Compound isolated | |
| Disease | 6 RANDOMIZED DOUBLE-BLIND TRIALS INCLUDED A TOTAL OF 651 OUTPATIENTS WITH MILD TO MODERATELY SEVERE DEPRESSIVE DISORDERS. 2 TRIALS WERE PLACEBO CONTROLLED AND 4 TRIALS COMPARED HYPERICUM PERFORATUM WITH TRICYCLIC ANTIDEPRESSANT (TCA) TREATMENTS. RESULTS SHOWED THAT HYPERICUM WAS 1.5 TIMES MORE LIKELY TO RESULT IN AN ANTIDEPRESSANT RESPONSE THAN PLACEBO TO TCAS. ALSO MORE SIDE EFFECTS WERE NOTED WITH TCAS. (DIFFERENT PREPARATIONS AND DOSAGES WERE USED). 64% RESPONDED TO HYPERICUM AND 66.4% TO THE TCAS. DROP-OUT RATES FOR TCAS WERE 16.2% AND FOR HYPERCIUM WERE 12.6%. A COMMERCIAL PRODUCT, ESBERICUM, WAS USED. |
| Dose amount | VAR |
| Number | 1 |
| Qualitative result | ACTIVE |
| Animal | HUMAN ADULT |
| Dose expression | DOSE |
| Extract | HYDRO-ALCOHOLIC EXT |
| Gender | GIVEN TO BOTH SEXES |