Experiment 635192
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | INTRAGASTRIC |
| Organism | Capsicum annuum (SOLANACEAE) |
| Citation | CRUZ,L: CASTANEDA-HERNANDEZ,G: NAVARRETE,A:. (1999). INGESTION OF CHILLI PEPPER (CAPSICUM ANNUUM) REDUCES SALICYLATE BIOAVAILABILITY AFTER ORAL ASPIRIN ADMINISTRATION IN THE RAT.. 77(6) |
| Amount utilized | |
| Compound isolated | |
| Disease | THE BIOAVAILABILITIES OF ASPIRIN (ACETYLSALICYLIC ACID) AND OF SALICYLIC ACID WERE STUDIED IN MALE WISTAR RATS AFTER ACUTE AND CHRONIC ADMINISTRATION OF A CAPSICUM ANNUUM EXTRACT, CONTAINING 100 MG OF CAPSAICIN PER GRAM. WITH A SINGLE ADMINISTRATION OF 100 MG/KG OF THE EXTRACT, ASPIRIN BLOOD LEVELS REMAINED UNCHANGED, BUT SALICYLIC ACID BIOAVAILABILITY WAS REDUCED IN 44% COMPARED WITH CONTROL ANIMALS. WITH A SINGLE ADMINISTRATION OF 300 MG/KG OF THE EXTRACT, ASPIRIN BLOOD LEVELS WERE UNDETECTABLE WHILE SALICYLIC ACID BIOAVAILABILITY WAS REDUCED IN 59%. CHRONIC ADMINISTRATION ONCE DAILY FOR 4 WEEKS OF 100 AND 300 MG/KG OF THE EXTRACT RESULTED IN UNDETECTED ASPIRIN BLOOD LEVELS, WHILE SALICYLIC ACID BIO AVAILABILITY WAS REDUCED IN 63 AND 76%, RESPECTIVELY, COMPARED WITH CONTROLS. RESULTS SHOW THAT CAPSICUM INGESTION REDUCED ORAL DRUG BIOAVAILABILITY, LIKELY AS A RESULT OF THE GASTROINTESTINAL EFFECTS OF CAPSAICIN. |
| Dose amount | 300.0 MG |
| Number | 1 |
| Qualitative result | ACTIVE |
| Animal | RAT |
| Per unit | GM |
| Dose expression | DOSE |
| Extract | TYPE EXT NOT STATED |
| Gender | MALE |