Experiment 635324
Worktypes
Compounds isolated
Details
| Property | Value |
|---|---|
| Pharmacology | |
| Administration route | EXTERNAL |
| Organism | Empty organism |
| Citation | LEDEZMA,E: LOPEZ,JC: MARIN,P: ROMERO,H: FERRARA,G: DE SOUSA,L: JORQUERA,A: CASTRO,KA:. (1999). AJOENE IN THE TOPICAL SHORT-TERM TREATMENT OF TINEA CRURIS AND TINEA CORPORIS IN HUMANS.. 49(6) |
| Amount utilized | |
| Compound isolated | |
| Disease | THE OBJECTIVE OF THIS WORK WAS TO COMPARE THE SAFETY AND EFFECTIVENESS OF AJOENE (0.6% GEL) WITH TERBINAFINE (1% CREAM) FOR THE TREATMENT OF TINEA CORPORIS AND TINEA CRURIS. THE PATIENTS SELECTED WERE 60 SOLDIERS WITH CLINICAL AND MYCOLOGICAL DIAGNOSIS OF EITHER DERMATOPHYTOSIS. THEY WERE DISTRIBUTED AT RANDOM IN TWO TREATMENT GROUPS. ONE TREATED WITH AJOENE AT 0.6% AND THE OTHER WITH TERBINAFINE AT 1%. ALL PATIENTS WERE EVALUATED CLINICALLY AND MYCOLOGICALLY 30 AND 60 DAYS AFTER COMPLETION OF THE TREATMENT, WHICH WAS CONSIDERED EFFECTIVE WHEN CLINICAL SIGNS AND SYMPTOMS HAD DISAPEARED AND THE MYCOLOGICAL CULTURES WERE NEGATIVE. 30 DAYS AFTER TREATMENT, THE PERCENT HEALING RATE WAS 77 AND 75 FOR THE GROUPS TREATED WITH AJOENE AND TERBINAFINE, RESPECTIVELY. 60 DAYS AFTER TREATMENT, THE HEALING RATE 73% AND 71% FOR THE GROUPS TREATED WITH AJOENE AND TERBINAFINE, RESPECTIVELY. THESE RESULTS AND THOSE OBTAINED IN PREVIOUS STUDIES CONFIRM THAT AJOENE IS A NEW AGENT FOR THE TOPIC TREATMENT OF SUPERFICIAL MYCOSES, AND FOR THE FIRST TIME SHOW THE THERAPEUTIC USEFULNESS OF AN INHIBITOR OF PHOSPHOLIPIDS BIOSYNTHESIS IN EUKARYOTES. |
| Dose amount | 0.6% |
| Number | 1 |
| Qualitative result | ACTIVE |
| Animal | HUMAN ADULT |
| Dose expression | CONC USED |
| Gender | MALE |