Experiment 635325

Worktypes

Details

PropertyValue
Pharmacology
Administration routeSC
OrganismViscum album (LORANTHACEAE)
CitationSTOSS,M: VAN WELY,M: MUSIELSKY,H: GORTER,RW:. (1999). STUDY ON LOCAL INFLAMMATORY REACTIONS AND OTHER PARAMETERS DURING SUBCUTANEOUS MISTLETOE APPLICATION IN HIV-POSITIVE PATIENTS AND HIV-NEGATIVE SUBJECTS OVER A PERIOD OF 18 WEEKS.. 49(4)
Amount utilized
Compound isolated
Disease1 COHORTS CONSISTING OF 30 HIV-ANTIBODY-POSITIVE PATIENTS AND 17 HEALTHY NON-SMOKERS WERE RANDOMLY ASSIGNED TO 2 GROUPS. THEY RECEIVED VAQUFRF AN AQUEOUS EXTRACT OF VISCUM ALBUM L. GROWN IN OAK TREES, A FERMENTED AQUENOUS EXTRACT. THE HIV- POSITIVE PATIENTS AND HIV-NEGATIVE SUBJECTS WERE RANDOMLY ASSIGNED TO ONE OF TWO DIFFERENT TREATMENT GROUPS AFTER THREE BASELINE EXAMINATIONS AT INTERVALS OF 7 DAYS. AFTER THE INITIAL 2 INJECTIONS, THE FIRST EXAMINATION WAS CONDUCTED AND THE FIRST BLOOD SAMPLE WAS TAKEN. ALL SUBSEQUENT CONTROL EXAMINATIONS WERE CONDUCTED AT INTERVALS OF 14 DAYS. THE APPLICATION SCHEDULE INVOLVED 2 INJECTIONS PER WEEK AT DOSES SHOWN TABLE 2. AT EACH VISIT THE INJECTION SITE FOR OCCURANCE OF ERYTHEMA INDURATION, SWELLING, PURITUS, PAIN AND DOCUMENTED. IN THE HIV-POSITIVE PATIENTS, THERE WAS A SIGNIFICANTLY LESS FREQUENT OCCURRENCE OF ERYTHEMA IN HTE DOSE RANGE <1.0 MG AND <5.0 MG, BUT MUCH HIGHER AT 1.2 MG. IN HIV-NEGATIVES, THERE WAS MORE REPORTS OF INDURATION AT <1.0 MG AND MORE PAIN AND PURITUS AT <5.0 MG.
Dose amountVAR
Number1
Qualitative resultACTIVE
AnimalHUMAN ADULT
Dose expressionDOSE
ExtractH2O EXT
GenderGIVEN TO BOTH SEXES